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Title: Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis
Authors: Datta, Arpita 
Deng, Shuo 
Gopal, Vennila
Yap, Kenneth Chun-Hong 
Halim, Clarissa Esmeralda 
Lye, Mun Leng
Ong, Mei Shan 
Tan, Tuan Zea 
Sethi, Gautam 
Hooi, Shing Chuan 
Kumar, Alan Prem 
Yap, Celestial T 
Keywords: Science & Technology
Life Sciences & Biomedicine
actin cytoskeleton
epithelial to mesenchymal transition
multidrug resistance
Issue Date: 1-Apr-2021
Publisher: MDPI
Citation: Datta, Arpita, Deng, Shuo, Gopal, Vennila, Yap, Kenneth Chun-Hong, Halim, Clarissa Esmeralda, Lye, Mun Leng, Ong, Mei Shan, Tan, Tuan Zea, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T (2021-04-01). Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis. CANCERS 13 (8). ScholarBank@NUS Repository.
Abstract: In cancer cells, a vital cellular process during metastasis is the transformation of epithelial cells towards motile mesenchymal cells called the epithelial to mesenchymal transition (EMT). The cytoskeleton is an active network of three intracellular filaments: actin cytoskeleton, microtubules, and intermediate filaments. These filaments play a central role in the structural design and cell behavior and are necessary for EMT. During EMT, epithelial cells undergo a cellular transformation as manifested by cell elongation, migration, and invasion, coordinated by actin cytoskeleton reor-ganization. The actin cytoskeleton is an extremely dynamic structure, controlled by a balance of assembly and disassembly of actin filaments. Actin-binding proteins regulate the process of actin polymerization and depolymerization. Microtubule reorganization also plays an important role in cell migration and polarization. Intermediate filaments are rearranged, switching to a vimentin-rich network, and this protein is used as a marker for a mesenchymal cell. Hence, targeting EMT by regulating the activities of their key components may be a potential solution to metastasis. This review summarizes the research done on the physiological functions of the cytoskeleton, its role in the EMT process, and its effect on multidrug-resistant (MDR) cancer cells—highlight some future perspectives in cancer therapy by targeting cytoskeleton.
Source Title: CANCERS
ISSN: 20726694
DOI: 10.3390/cancers13081882
Appears in Collections:Staff Publications

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