Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers13081882
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dc.titleCytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis
dc.contributor.authorDatta, Arpita
dc.contributor.authorDeng, Shuo
dc.contributor.authorGopal, Vennila
dc.contributor.authorYap, Kenneth Chun-Hong
dc.contributor.authorHalim, Clarissa Esmeralda
dc.contributor.authorLye, Mun Leng
dc.contributor.authorOng, Mei Shan
dc.contributor.authorTan, Tuan Zea
dc.contributor.authorSethi, Gautam
dc.contributor.authorHooi, Shing Chuan
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorYap, Celestial T
dc.date.accessioned2022-04-08T08:20:49Z
dc.date.available2022-04-08T08:20:49Z
dc.date.issued2021-04-01
dc.identifier.citationDatta, Arpita, Deng, Shuo, Gopal, Vennila, Yap, Kenneth Chun-Hong, Halim, Clarissa Esmeralda, Lye, Mun Leng, Ong, Mei Shan, Tan, Tuan Zea, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T (2021-04-01). Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis. CANCERS 13 (8). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13081882
dc.identifier.issn20726694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218777
dc.description.abstractIn cancer cells, a vital cellular process during metastasis is the transformation of epithelial cells towards motile mesenchymal cells called the epithelial to mesenchymal transition (EMT). The cytoskeleton is an active network of three intracellular filaments: actin cytoskeleton, microtubules, and intermediate filaments. These filaments play a central role in the structural design and cell behavior and are necessary for EMT. During EMT, epithelial cells undergo a cellular transformation as manifested by cell elongation, migration, and invasion, coordinated by actin cytoskeleton reor-ganization. The actin cytoskeleton is an extremely dynamic structure, controlled by a balance of assembly and disassembly of actin filaments. Actin-binding proteins regulate the process of actin polymerization and depolymerization. Microtubule reorganization also plays an important role in cell migration and polarization. Intermediate filaments are rearranged, switching to a vimentin-rich network, and this protein is used as a marker for a mesenchymal cell. Hence, targeting EMT by regulating the activities of their key components may be a potential solution to metastasis. This review summarizes the research done on the physiological functions of the cytoskeleton, its role in the EMT process, and its effect on multidrug-resistant (MDR) cancer cells—highlight some future perspectives in cancer therapy by targeting cytoskeleton.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectOncology
dc.subjectactin cytoskeleton
dc.subjectepithelial to mesenchymal transition
dc.subjectmetastasis
dc.subjectmultidrug resistance
dc.typeReview
dc.date.updated2022-04-07T07:24:00Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.3390/cancers13081882
dc.description.sourcetitleCANCERS
dc.description.volume13
dc.description.issue8
dc.published.statePublished
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