Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.transproceed.2015.12.082
Title: Compensatory Hypertrophy After Living Donor Nephrectomy
Authors: Chen, KW
Wu, MWF
Chen, Z
Tai, BC 
Goh, YSB
Lata, R
Vathsala, A
Tiong, HY
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Surgery
Transplantation
CHRONIC KIDNEY-DISEASE
RENAL HYPERTROPHY
RADICAL NEPHRECTOMY
VOLUME
OUTCOMES
ADULTS
RISK
Issue Date: 1-Apr-2016
Publisher: ELSEVIER SCIENCE INC
Citation: Chen, KW, Wu, MWF, Chen, Z, Tai, BC, Goh, YSB, Lata, R, Vathsala, A, Tiong, HY (2016-04-01). Compensatory Hypertrophy After Living Donor Nephrectomy. TRANSPLANTATION PROCEEDINGS 48 (3) : 716-719. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2015.12.082
Abstract: Background Previous studies have shown that kidney volume enhances the estimation of glomerular filtration rate (eGFR) in kidney donors. This study aimed to describe the phenomenon of compensatory hypertrophy after donor nephrectomy as measured on computerized tomographic (CT) scans. Methods An institutional Domain Specific Review Board (DSRB)-approved study involved approaching kidney donors to have a follow up CT scan from 6 months to 1 year after surgery; 29 patients participated; 55% were female. Clinical chart review was performed, and the patient's remaining kidney volume was measured before and after surgery based on CT scans. eGFR was determined with the use of the Modification of Diet in Renal Disease equation. Results Mean parenchymal volume of the remaining kidney for this population (mean age, 44.3 ± 8.5 y) was 204.7 ± 82.5 cc before surgery and 250.5 ± 113.3 cc after donor nephrectomy. Compensatory hypertrophy occurred in 79.3% of patients (n = 23). Mean increase in remaining kidney volume was 22.4 ± 23.2% after donor nephrectomy in healthy individuals. Over a median follow-up of 52.9 ± 19.8 months, mean eGFR was 68.9 ± 12.4 mL/min/1.73 m2, with 24.1% of patients (n = 7) in chronic kidney disease grade 3. Absolute and relative change in kidney volume was not associated with sex, race, surgical approach, or background of hypertension (P = NS). There was a trend of decreased hypertrophy with increasing age (P =.5; Spearman correlation, -0.12). Conclusions In healthy kidney donors, compensatory hypertrophy of the remaining kidney occurs in 79.3% of the patients, with an average increment of about 22.4%. Older patients may have a blunted compensatory hypertrophy response after surgery.
Source Title: TRANSPLANTATION PROCEEDINGS
URI: https://scholarbank.nus.edu.sg/handle/10635/217021
ISSN: 0041-1345
1873-2623
DOI: 10.1016/j.transproceed.2015.12.082
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