Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.transproceed.2015.12.082
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dc.titleCompensatory Hypertrophy After Living Donor Nephrectomy
dc.contributor.authorChen, KW
dc.contributor.authorWu, MWF
dc.contributor.authorChen, Z
dc.contributor.authorTai, BC
dc.contributor.authorGoh, YSB
dc.contributor.authorLata, R
dc.contributor.authorVathsala, A
dc.contributor.authorTiong, HY
dc.date.accessioned2022-03-14T01:59:02Z
dc.date.available2022-03-14T01:59:02Z
dc.date.issued2016-04-01
dc.identifier.citationChen, KW, Wu, MWF, Chen, Z, Tai, BC, Goh, YSB, Lata, R, Vathsala, A, Tiong, HY (2016-04-01). Compensatory Hypertrophy After Living Donor Nephrectomy. TRANSPLANTATION PROCEEDINGS 48 (3) : 716-719. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2015.12.082
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/217021
dc.description.abstractBackground Previous studies have shown that kidney volume enhances the estimation of glomerular filtration rate (eGFR) in kidney donors. This study aimed to describe the phenomenon of compensatory hypertrophy after donor nephrectomy as measured on computerized tomographic (CT) scans. Methods An institutional Domain Specific Review Board (DSRB)-approved study involved approaching kidney donors to have a follow up CT scan from 6 months to 1 year after surgery; 29 patients participated; 55% were female. Clinical chart review was performed, and the patient's remaining kidney volume was measured before and after surgery based on CT scans. eGFR was determined with the use of the Modification of Diet in Renal Disease equation. Results Mean parenchymal volume of the remaining kidney for this population (mean age, 44.3 ± 8.5 y) was 204.7 ± 82.5 cc before surgery and 250.5 ± 113.3 cc after donor nephrectomy. Compensatory hypertrophy occurred in 79.3% of patients (n = 23). Mean increase in remaining kidney volume was 22.4 ± 23.2% after donor nephrectomy in healthy individuals. Over a median follow-up of 52.9 ± 19.8 months, mean eGFR was 68.9 ± 12.4 mL/min/1.73 m2, with 24.1% of patients (n = 7) in chronic kidney disease grade 3. Absolute and relative change in kidney volume was not associated with sex, race, surgical approach, or background of hypertension (P = NS). There was a trend of decreased hypertrophy with increasing age (P =.5; Spearman correlation, -0.12). Conclusions In healthy kidney donors, compensatory hypertrophy of the remaining kidney occurs in 79.3% of the patients, with an average increment of about 22.4%. Older patients may have a blunted compensatory hypertrophy response after surgery.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectImmunology
dc.subjectSurgery
dc.subjectTransplantation
dc.subjectCHRONIC KIDNEY-DISEASE
dc.subjectRENAL HYPERTROPHY
dc.subjectRADICAL NEPHRECTOMY
dc.subjectVOLUME
dc.subjectOUTCOMES
dc.subjectADULTS
dc.subjectRISK
dc.typeArticle
dc.date.updated2022-03-13T10:02:14Z
dc.contributor.departmentSINGAPORE-MIT ALLIANCE
dc.description.doi10.1016/j.transproceed.2015.12.082
dc.description.sourcetitleTRANSPLANTATION PROCEEDINGS
dc.description.volume48
dc.description.issue3
dc.description.page716-719
dc.description.placeUNITED KINGDOM
dc.published.statePublished
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