Please use this identifier to cite or link to this item: https://doi.org/10.1210/clinem/dgaa211
Title: Maternal Glycemia During Pregnancy and Child Carotid Intima Media Thickness, Pulse Wave Velocity, and Augmentation Index
Authors: Yuan, Wen Lun 
Lin, Jinjie
Kramer, Michael S 
Godfrey, Keith M
Gluckman, Peter D 
Chong, Yap-Seng 
Shek, Lynette P 
Tan, Kok Hian 
Chan, Shiao-Yng
Eriksson, Johan G 
Yap, Fabian 
Lee, Yung Seng 
Choo, Jonathan TL
Ling, Lieng Hsi 
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
maternal glycemia
pregnancy
children
cIMT
PWV
Alx
ARTERIAL STIFFNESS
BLOOD-PRESSURE
TASK-FORCE
RISK
HYPERGLYCEMIA
EXPOSURE
DISEASE
HEALTH
Issue Date: 1-Jul-2020
Publisher: ENDOCRINE SOC
Citation: Yuan, Wen Lun, Lin, Jinjie, Kramer, Michael S, Godfrey, Keith M, Gluckman, Peter D, Chong, Yap-Seng, Shek, Lynette P, Tan, Kok Hian, Chan, Shiao-Yng, Eriksson, Johan G, Yap, Fabian, Lee, Yung Seng, Choo, Jonathan TL, Ling, Lieng Hsi (2020-07-01). Maternal Glycemia During Pregnancy and Child Carotid Intima Media Thickness, Pulse Wave Velocity, and Augmentation Index. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 105 (7) : E2581-E2590. ScholarBank@NUS Repository. https://doi.org/10.1210/clinem/dgaa211
Abstract: Background: In women without diabetes, little is known about the consequences of hyperglycemia during pregnancy for the offspring's cardiovascular structure and function. Objective: To investigate the association of maternal glycemia during pregnancy with cardiovascular risk markers in their children in GUSTO, a Singaporean birth cohort study. Methods: Around 26 weeks' gestation, a 75 g oral glucose tolerance test was performed and fasting plasma glucose (FPG) and 2-hour postprandial plasma glucose (PPPG) concentrations were measured. Gestational diabetes mellitus (GDM) was defined using WHO 1999 diagnostic criteria. At 6 years of age, we measured the child's carotid intima-media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and blood pressure (BP). Association of maternal glycemia during pregnancy with cardiovascular risk markers in their children were analyzed using multiple linear and logistic regressions. Results: Analysis were performed on 479 mother-child dyads. Higher maternal FPG was associated with higher cIMT and, in males, with a higher cfPWV in the offspring (adjusted β [CI 95%], cIMT: 0.08 per 10mm increase [0.02; 0.15], cfPWV: 0.36 m/s [0.01; 0.70]). Higher 2-hour PPPG was associated with higher cfPWV and AIx. Gestational diabetes mellitus was associated with higher AIx. No association was found between maternal glycemia and their offspring blood pressure. Conclusions: among mothers without pre-existing diabetes, higher glycemia during pregnancy was associated with mild structural and functional vascular changes in their children at 6 years of age across a continuum. These results support the necessity to monitor maternal glycemia during pregnancy even in the absence of pre-existing diabetes or diagnosed GDM.
Source Title: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
URI: https://scholarbank.nus.edu.sg/handle/10635/216307
ISSN: 0021972X
19457197
DOI: 10.1210/clinem/dgaa211
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Maternal Glycemia During Pregnancy and Child Carotid Intima Media Thickness, Pulse Wave Velocity, and Augmentation Index.pdfPublished version624.56 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

5
checked on Jan 26, 2023

Page view(s)

91
checked on Jan 26, 2023

Download(s)

1
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.