Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41366-021-00975-3
Title: | Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution | Authors: | Tan, Karen Tint, Mya Thway Michael, Navin Yap, Fabian Chong, Yap Seng Tan, Kok Hian Godfrey, Keith M Larbi, Anis Lee, Yung Seng Chan, Shiao-Yng Fortier, Marielle Eriksson, Johan G Karnani, Neerja |
Keywords: | Science & Technology Life Sciences & Biomedicine Endocrinology & Metabolism Nutrition & Dietetics HIGH-MOLECULAR-WEIGHT PLASMA ADIPONECTIN LEVELS SERUM ADIPONECTIN LEPTIN CONCENTRATIONS BIRTH-WEIGHT INSULIN-RESISTANCE NEWBORN-INFANTS MATERNAL SERUM BODY-FAT CHILDREN |
Issue Date: | 4-Dec-2021 | Publisher: | SPRINGERNATURE | Citation: | Tan, Karen, Tint, Mya Thway, Michael, Navin, Yap, Fabian, Chong, Yap Seng, Tan, Kok Hian, Godfrey, Keith M, Larbi, Anis, Lee, Yung Seng, Chan, Shiao-Yng, Fortier, Marielle, Eriksson, Johan G, Karnani, Neerja (2021-12-04). Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution. INTERNATIONAL JOURNAL OF OBESITY. ScholarBank@NUS Repository. https://doi.org/10.1038/s41366-021-00975-3 | Abstract: | Background: Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother–offspring cohort. Methods: Growing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother–offspring birth cohort study in Singapore. Cord blood plasma leptin and adiponectin concentrations were measured using Luminex and Enzyme-Linked Immunosorbent Assay respectively in 816 infants. A total of 271 neonates underwent MRI within the first 2-weeks after delivery. Abdominal superficial (sSAT), deep subcutaneous (dSAT), and intra-abdominal (IAT) adipose tissue compartment volumes were quantified from MRI images. Multivariable regression analyses were performed. Results: Indian or Malay ethnicity, female sex, and gestational age were positively associated with cord blood leptin and adiponectin concentrations. Maternal gestational diabetes (GDM) positively associated with cord blood leptin concentrations but inversely associated with cord blood adiponectin concentrations. Maternal pre-pregnancy body mass index (BMI) showed a positive relationship with cord blood leptin but not with adiponectin concentrations. Each SD increase in cord blood leptin was associated with higher neonatal sSAT, dSAT and IAT; differences in SD (95% CI): 0.258 (0.142, 0.374), 0.386 (0.254, 0.517) and 0.250 (0.118, 0.383), respectively. Similarly, each SD increase in cord blood adiponectin was associated with higher neonatal sSAT and dSAT; differences in SD (95% CI): 0.185 (0.096, 0.274) and 0.173 (0.067, 0.278), respectively. The association between cord blood adiponectin and neonatal adiposity was observed in neonates of obese mothers only. Conclusions: Cord blood leptin and adiponectin concentrations were associated with ethnicity, maternal BMI and GDM, sex and gestational age. Both adipokines showed positive association with neonatal abdominal adiposity. | Source Title: | INTERNATIONAL JOURNAL OF OBESITY | URI: | https://scholarbank.nus.edu.sg/handle/10635/216304 | ISSN: | 03070565 14765497 |
DOI: | 10.1038/s41366-021-00975-3 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.pdf | Published version | 1.65 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.