Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41366-021-00975-3
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dc.titleDeterminants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution
dc.contributor.authorTan, Karen
dc.contributor.authorTint, Mya Thway
dc.contributor.authorMichael, Navin
dc.contributor.authorYap, Fabian
dc.contributor.authorChong, Yap Seng
dc.contributor.authorTan, Kok Hian
dc.contributor.authorGodfrey, Keith M
dc.contributor.authorLarbi, Anis
dc.contributor.authorLee, Yung Seng
dc.contributor.authorChan, Shiao-Yng
dc.contributor.authorFortier, Marielle
dc.contributor.authorEriksson, Johan G
dc.contributor.authorKarnani, Neerja
dc.date.accessioned2022-02-25T08:58:21Z
dc.date.available2022-02-25T08:58:21Z
dc.date.issued2021-12-04
dc.identifier.citationTan, Karen, Tint, Mya Thway, Michael, Navin, Yap, Fabian, Chong, Yap Seng, Tan, Kok Hian, Godfrey, Keith M, Larbi, Anis, Lee, Yung Seng, Chan, Shiao-Yng, Fortier, Marielle, Eriksson, Johan G, Karnani, Neerja (2021-12-04). Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution. INTERNATIONAL JOURNAL OF OBESITY. ScholarBank@NUS Repository. https://doi.org/10.1038/s41366-021-00975-3
dc.identifier.issn03070565
dc.identifier.issn14765497
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/216304
dc.description.abstractBackground: Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother–offspring cohort. Methods: Growing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother–offspring birth cohort study in Singapore. Cord blood plasma leptin and adiponectin concentrations were measured using Luminex and Enzyme-Linked Immunosorbent Assay respectively in 816 infants. A total of 271 neonates underwent MRI within the first 2-weeks after delivery. Abdominal superficial (sSAT), deep subcutaneous (dSAT), and intra-abdominal (IAT) adipose tissue compartment volumes were quantified from MRI images. Multivariable regression analyses were performed. Results: Indian or Malay ethnicity, female sex, and gestational age were positively associated with cord blood leptin and adiponectin concentrations. Maternal gestational diabetes (GDM) positively associated with cord blood leptin concentrations but inversely associated with cord blood adiponectin concentrations. Maternal pre-pregnancy body mass index (BMI) showed a positive relationship with cord blood leptin but not with adiponectin concentrations. Each SD increase in cord blood leptin was associated with higher neonatal sSAT, dSAT and IAT; differences in SD (95% CI): 0.258 (0.142, 0.374), 0.386 (0.254, 0.517) and 0.250 (0.118, 0.383), respectively. Similarly, each SD increase in cord blood adiponectin was associated with higher neonatal sSAT and dSAT; differences in SD (95% CI): 0.185 (0.096, 0.274) and 0.173 (0.067, 0.278), respectively. The association between cord blood adiponectin and neonatal adiposity was observed in neonates of obese mothers only. Conclusions: Cord blood leptin and adiponectin concentrations were associated with ethnicity, maternal BMI and GDM, sex and gestational age. Both adipokines showed positive association with neonatal abdominal adiposity.
dc.language.isoen
dc.publisherSPRINGERNATURE
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEndocrinology & Metabolism
dc.subjectNutrition & Dietetics
dc.subjectHIGH-MOLECULAR-WEIGHT
dc.subjectPLASMA ADIPONECTIN LEVELS
dc.subjectSERUM ADIPONECTIN
dc.subjectLEPTIN CONCENTRATIONS
dc.subjectBIRTH-WEIGHT
dc.subjectINSULIN-RESISTANCE
dc.subjectNEWBORN-INFANTS
dc.subjectMATERNAL SERUM
dc.subjectBODY-FAT
dc.subjectCHILDREN
dc.typeArticle
dc.date.updated2022-02-24T06:19:24Z
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41366-021-00975-3
dc.description.sourcetitleINTERNATIONAL JOURNAL OF OBESITY
dc.published.statePublished
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