Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00394-022-02800-7
Title: Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero
Authors: Ong, Yi Ying 
Pang, Wei Wei 
Huang, Jonathan Y
Aris, Izzuddin M
Sadananthan, Suresh Anand 
Tint, Mya-Thway 
Yuan, Wen Lun 
Chen, Ling-Wei 
Chan, Yiong Huak 
Karnani, Neerja 
Velan, S Sendhil
Fortier, Marielle
Choo, Jonathan
Ling, Lieng Hsi 
Shek, Lynette 
Tan, Kok Hian 
Gluckman, Peter D 
Yap, Fabian 
Chong, Yap-Seng 
Godfrey, Keith M
Chong, Mary F-F 
Chan, Shiao-Yng
Eriksson, Johan G 
Wlodek, Mary E
Lee, Yung Seng 
Michael, Navin
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
Breastfeeding
Gestational diabetes
Glycemia
Cardiometabolic risk
Fat partitioning
Adiposity
LONG-TERM IMPACT
DIABETES-MELLITUS
GLUCOSE-TOLERANCE
INSULIN-RESISTANCE
MATERNAL GLYCEMIA
EARLY-CHILDHOOD
PLASMA-GLUCOSE
BLOOD-PRESSURE
HUMAN-MILK
OBESITY
Issue Date: 6-Feb-2022
Publisher: SPRINGER HEIDELBERG
Citation: Ong, Yi Ying, Pang, Wei Wei, Huang, Jonathan Y, Aris, Izzuddin M, Sadananthan, Suresh Anand, Tint, Mya-Thway, Yuan, Wen Lun, Chen, Ling-Wei, Chan, Yiong Huak, Karnani, Neerja, Velan, S Sendhil, Fortier, Marielle, Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Tan, Kok Hian, Gluckman, Peter D, Yap, Fabian, Chong, Yap-Seng, Godfrey, Keith M, Chong, Mary F-F, Chan, Shiao-Yng, Eriksson, Johan G, Wlodek, Mary E, Lee, Yung Seng, Michael, Navin (2022-02-06). Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero. EUROPEAN JOURNAL OF NUTRITION. ScholarBank@NUS Repository. https://doi.org/10.1007/s00394-022-02800-7
Abstract: Purpose: There is altered breastmilk composition among mothers with gestational diabetes and conflicting evidence on whether breastfeeding is beneficial or detrimental to their offspring’s cardiometabolic health. We aimed to investigate associations between breastfeeding and offspring’s cardiometabolic health across the range of gestational glycemia. Methods: We included 827 naturally conceived, term singletons from a prospective mother–child cohort. We measured gestational (26–28 weeks) fasting plasma glucose (FPG) and 2-h plasma glucose (2 hPG) after an oral glucose tolerance test as continuous variables. Participants were classified into 2 breastfeeding categories (high/intermediate vs. low) according to their breastfeeding duration and exclusivity. Main outcome measures included magnetic resonance imaging (MRI)-measured abdominal fat, intramyocellular lipids (IMCL), and liver fat, quantitative magnetic resonance (QMR)-measured body fat mass, blood pressure, blood lipids, and insulin resistance at 6 years old (all continuous variables). We evaluated if gestational glycemia (FPG and 2 hPG) modified the association of breastfeeding with offspring outcomes after adjusting for confounders using a multiple linear regression model that included a ‘gestational glycemia × breastfeeding’ interaction term. Results: With increasing gestational FPG, high/intermediate (vs. low) breastfeeding was associated with lower levels of IMCL (p-interaction = 0.047), liver fat (p-interaction = 0.033), and triglycerides (p-interaction = 0.007), after adjusting for confounders. Specifically, at 2 standard deviations above the mean gestational FPG level, high/intermediate (vs. low) breastfeeding was linked to lower adjusted mean IMCL [0.39% of water signal (0.29, 0.50) vs. 0.54% of water signal (0.46, 0.62)], liver fat [0.39% by weight (0.20, 0.58) vs. 0.72% by weight (0.59, 0.85)], and triglycerides [0.62 mmol/L (0.51, 0.72) vs. 0.86 mmol/L (0.75, 0.97)]. 2 hPG did not significantly modify the association between breastfeeding and childhood cardiometabolic risk. Conclusion: Our findings suggest breastfeeding may confer protection against adverse fat partitioning and higher triglyceride concentration among children exposed to increased glycemia in utero.
Source Title: EUROPEAN JOURNAL OF NUTRITION
URI: https://scholarbank.nus.edu.sg/handle/10635/216302
ISSN: 14366207
14366215
DOI: 10.1007/s00394-022-02800-7
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