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Title: The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity.
Authors: Tan, Karen Mei-Ling 
Tint, Mya-Thway 
Kothandaraman, Narasimhan 
Michael, Navin
Sadananthan, Suresh Anand 
Velan, S Sendhil
Fortier, Marielle V
Yap, Fabian 
Tan, Kok Hian 
Gluckman, Peter D 
Chong, Yap-Seng 
Chong, Mary FF 
Lee, Yung Seng 
Godfrey, Keith M
Eriksson, Johan G
Cameron-Smith, David
Keywords: GUSTO
cord blood
kynurenine pathway
neonatal adiposity
Issue Date: 12-Feb-2022
Publisher: The Endocrine Society
Citation: Tan, Karen Mei-Ling, Tint, Mya-Thway, Kothandaraman, Narasimhan, Michael, Navin, Sadananthan, Suresh Anand, Velan, S Sendhil, Fortier, Marielle V, Yap, Fabian, Tan, Kok Hian, Gluckman, Peter D, Chong, Yap-Seng, Chong, Mary FF, Lee, Yung Seng, Godfrey, Keith M, Eriksson, Johan G, Cameron-Smith, David (2022-02-12). The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity.. J Clin Endocrinol Metab. ScholarBank@NUS Repository.
Abstract: BACKGROUND: The kynurenine pathway generates metabolites integral to energy metabolism, neurotransmission, and immune function. Circulating kynurenine metabolites positively correlate with adiposity in children and adults, yet it is not known whether this relationship is present already at birth. In this prospective longitudinal study, we investigate the relationship between cord blood kynurenine metabolites and measures of adiposity from birth to 4.5 years. METHODS: Liquid chromatography-tandem mass spectrometry was used to quantify cord blood kynurenine metabolites in 812 neonates from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. Fat percentage was measured by air displacement plyethysmography and abdominal adipose tissue compartment volumes; superficial (sSAT) and deep subcutaneous (dSAT) and internal adipose tissue were quantified by magnetic resonance imaging at early infancy in a smaller subset of neonates, and again at 4 - 4.5 years of age. RESULTS: Cord blood kynurenine metabolites appeared to be higher in female newborns, higher in Indian newborns compared to Chinese newborns, and higher in infants born by Caesarean section compared to by vaginal delivery. Kynurenine,xanthurenic acid and quinolinic acid were positively associated with birthweight, but not with subsequent weight during infancy and childhood. Quinolinic acid was positively associated with sSAT at birth. Kynurenic acid and quinolinic acid were positively associated with fat percentage at 4 years. CONCLUSION: Several cord blood kynurenine metabolite concentrations were positively associated with birthweight, with higher kynurenic acid and quinolinic acid correlating to higher percentage body fat in childhood, suggesting these cord blood metabolites as biomarkers of early childhood adiposity.
Source Title: J Clin Endocrinol Metab
ISSN: 0021972X
DOI: 10.1210/clinem/dgac078
Appears in Collections:Staff Publications

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