Please use this identifier to cite or link to this item: https://doi.org/10.1080/09273948.2020.1767791
Title: Singapore Ocular Tuberculosis Immunity Study (SPOTIS): Role of T-lymphocyte profiling in patients with presumed ocular tuberculosis
Authors: Paul Hutchinson 
Aera Kee
Rupesh Agrawal
Nobuyo Iwata 
Mayjane Tumulak
John Connolly 
Soon Phaik Chee 
Jay Siak 
Keywords: cell-mediated immune response4
ocular tuberculosis2
t cell6
t lymphocytes5
Tubercular uveitis1
tuberculosis3
Issue Date: 14-Jul-2020
Publisher: Taylor & Francis
Citation: Paul Hutchinson, Aera Kee, Rupesh Agrawal, Nobuyo Iwata, Mayjane Tumulak, John Connolly, Soon Phaik Chee, Jay Siak (2020-07-14). Singapore Ocular Tuberculosis Immunity Study (SPOTIS): Role of T-lymphocyte profiling in patients with presumed ocular tuberculosis. Ocular Immunology and Inflammation 29 (8-Jul) : 1489-1495. ScholarBank@NUS Repository. https://doi.org/10.1080/09273948.2020.1767791
Abstract: Objective: A prospective clinical study to assess the utility of CD4 + T cell lymphocyte profiling from peripheral blood in patients with ocular tuberculosis (TB). Methods: Thirty-six Asian patients with presumed diagnosis of ocular TB were recruited for T-lymphocyte profiling. MTB antigen specific CD4 assay was set up, and flow cytometric data were analyzed using FlowJo software. Results: There was no significant difference between treatment responders and non-responders for the proportion of CD4 + T cells specific for PPD or ESAT-6+ CFP-10, but treatment responders did have significantly higher frequency of CD38+ (p = .0357) and CD38+ HLA-DR+ (p = .0357) on the PPD-specific CD4 + T cells. Conclusion: This study is one of the first of its kind to look into MTB specific T cell activation marker profiling of peripheral blood in patients with ocular TB. Further studies need to be undertaken to assess the utility of CD4 + T cell phenotypes as a biomarker for ocular TB.
Source Title: Ocular Immunology and Inflammation
URI: https://scholarbank.nus.edu.sg/handle/10635/215745
ISSN: 0927-3948
DOI: 10.1080/09273948.2020.1767791
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