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https://doi.org/10.1002/advs.202004379
Title: | Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation | Authors: | Wang, Kang-Nan Liu, Liu-Yi Qi, Guobin Chao, Xi-Juan Ma, Wen Yu, Zhiqiang Pan, Qiling Mao, Zong-Wan Liu, Bin |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science functional iridium complex mitochondria‐ to‐ nucleus translocation nucleic acid damage photodynamic therapy RED FLUORESCENT-PROBES IRIDIUM(III) COMPLEX ANTICANCER METABOLISM |
Issue Date: | 8-Feb-2021 | Publisher: | WILEY | Citation: | Wang, Kang-Nan, Liu, Liu-Yi, Qi, Guobin, Chao, Xi-Juan, Ma, Wen, Yu, Zhiqiang, Pan, Qiling, Mao, Zong-Wan, Liu, Bin (2021-02-08). Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation. ADVANCED SCIENCE 8 (8). ScholarBank@NUS Repository. https://doi.org/10.1002/advs.202004379 | Abstract: | Nuclei and mitochondria are the only cellular organelles containing genes, which are specific targets for efficient cancer therapy. So far, several photosensitizers have been reported for mitochondria targeting, and another few have been reported for nuclei targeting. However, none have been reported for photosensitization in both mitochondria and nucleus, especially in cascade mode, which can significantly reduce the photosensitizers needed for maximal treatment effect. Herein, a light-driven, mitochondria-to-nucleus cascade dual organelle cancer cell ablation strategy is reported. A functionalized iridium complex, named BT-Ir, is designed as a photosensitizer, which targets mitochondria first for photosensitization and subsequently is translocated to a cell nucleus for continuous photodynamic cancer cell ablation. This strategy opens new opportunities for efficient photodynamic therapy. | Source Title: | ADVANCED SCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/215106 | ISSN: | 2198-3844,2198-3844 | DOI: | 10.1002/advs.202004379 |
Appears in Collections: | Staff Publications Elements |
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