Please use this identifier to cite or link to this item: https://doi.org/10.1002/advs.202004379
DC FieldValue
dc.titleLight-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation
dc.contributor.authorWang, Kang-Nan
dc.contributor.authorLiu, Liu-Yi
dc.contributor.authorQi, Guobin
dc.contributor.authorChao, Xi-Juan
dc.contributor.authorMa, Wen
dc.contributor.authorYu, Zhiqiang
dc.contributor.authorPan, Qiling
dc.contributor.authorMao, Zong-Wan
dc.contributor.authorLiu, Bin
dc.date.accessioned2022-02-09T09:58:22Z
dc.date.available2022-02-09T09:58:22Z
dc.date.issued2021-02-08
dc.identifier.citationWang, Kang-Nan, Liu, Liu-Yi, Qi, Guobin, Chao, Xi-Juan, Ma, Wen, Yu, Zhiqiang, Pan, Qiling, Mao, Zong-Wan, Liu, Bin (2021-02-08). Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation. ADVANCED SCIENCE 8 (8). ScholarBank@NUS Repository. https://doi.org/10.1002/advs.202004379
dc.identifier.issn2198-3844,2198-3844
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/215106
dc.description.abstractNuclei and mitochondria are the only cellular organelles containing genes, which are specific targets for efficient cancer therapy. So far, several photosensitizers have been reported for mitochondria targeting, and another few have been reported for nuclei targeting. However, none have been reported for photosensitization in both mitochondria and nucleus, especially in cascade mode, which can significantly reduce the photosensitizers needed for maximal treatment effect. Herein, a light-driven, mitochondria-to-nucleus cascade dual organelle cancer cell ablation strategy is reported. A functionalized iridium complex, named BT-Ir, is designed as a photosensitizer, which targets mitochondria first for photosensitization and subsequently is translocated to a cell nucleus for continuous photodynamic cancer cell ablation. This strategy opens new opportunities for efficient photodynamic therapy.
dc.language.isoen
dc.publisherWILEY
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectfunctional iridium complex
dc.subjectmitochondria&#8208
dc.subjectto&#8208
dc.subjectnucleus translocation
dc.subjectnucleic acid damage
dc.subjectphotodynamic therapy
dc.subjectRED FLUORESCENT-PROBES
dc.subjectIRIDIUM(III) COMPLEX
dc.subjectANTICANCER
dc.subjectMETABOLISM
dc.typeArticle
dc.date.updated2022-02-09T09:20:50Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/advs.202004379
dc.description.sourcetitleADVANCED SCIENCE
dc.description.volume8
dc.description.issue8
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
manuscript_adv sci_revised.docxSubmitted version2.41 MBMicrosoft Word XML

OPEN

Post-printView/Download

SCOPUSTM   
Citations

24
checked on Nov 29, 2022

Page view(s)

85
checked on Dec 1, 2022

Download(s)

1
checked on Dec 1, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.