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Title: Circulating saturated fatty acids and incident type 2 diabetes: A systematic review and meta-analysis
Authors: Huang, L.
Lin, J.-S.
Aris, I.M. 
Yang, G.
Chen, W.-Q.
Li, L.-J.
Keywords: Circulating
Prospective cohort study
Saturated fatty acids
Systematic review
Type 2 diabetes
Issue Date: 2019
Publisher: MDPI AG
Citation: Huang, L., Lin, J.-S., Aris, I.M., Yang, G., Chen, W.-Q., Li, L.-J. (2019). Circulating saturated fatty acids and incident type 2 diabetes: A systematic review and meta-analysis. Nutrients 11 (5) : 998. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The effect of saturated fatty acids (SFAs) on incident type 2 diabetes (T2D) is controversial and few have systematically appraised the evidence. We conducted a comprehensive search of prospective studies examining these relationships that were published in PubMed, Web of Science, or EMBASE from 21 February 1989 to 21 February 2019. A total of 19 studies were included for systematic review and 10 for meta-analysis. We estimated the summarized relative risk (RR) and 95% confidence interval (95% CI) using a random (if I2 > 50%) or a fixed effects model (if I2 = 50%). Although the included studies reported inconclusive results, the majority supported a protective effect of odd-chain and an adverse impact of even-chain SFAs. Meta-analysis showed that the per standard deviation (SD) increase in odd-chain SFAs was associated with a reduced risk of incident T2D (C15:0: 0.86, 0.76-0.98; C17:0: 0.76, 0.59-0.97), while a per SD increase in one even-chain SFA was associated with an increased risk of incident T2D (C14:0: 1.13, 1.09-1.18). No associations were found between other SFAs and incident T2D. In conclusion, our findings suggest an overall protective effect of odd-chain SFAs and the inconclusive impact of even- and very-long-chain SFAs on incident T2D. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Nutrients
ISSN: 20726643
DOI: 10.3390/nu11050998
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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