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https://doi.org/10.3390/nu11050998
DC Field | Value | |
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dc.title | Circulating saturated fatty acids and incident type 2 diabetes: A systematic review and meta-analysis | |
dc.contributor.author | Huang, L. | |
dc.contributor.author | Lin, J.-S. | |
dc.contributor.author | Aris, I.M. | |
dc.contributor.author | Yang, G. | |
dc.contributor.author | Chen, W.-Q. | |
dc.contributor.author | Li, L.-J. | |
dc.date.accessioned | 2022-01-11T06:17:33Z | |
dc.date.available | 2022-01-11T06:17:33Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Huang, L., Lin, J.-S., Aris, I.M., Yang, G., Chen, W.-Q., Li, L.-J. (2019). Circulating saturated fatty acids and incident type 2 diabetes: A systematic review and meta-analysis. Nutrients 11 (5) : 998. ScholarBank@NUS Repository. https://doi.org/10.3390/nu11050998 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/213690 | |
dc.description.abstract | The effect of saturated fatty acids (SFAs) on incident type 2 diabetes (T2D) is controversial and few have systematically appraised the evidence. We conducted a comprehensive search of prospective studies examining these relationships that were published in PubMed, Web of Science, or EMBASE from 21 February 1989 to 21 February 2019. A total of 19 studies were included for systematic review and 10 for meta-analysis. We estimated the summarized relative risk (RR) and 95% confidence interval (95% CI) using a random (if I2 > 50%) or a fixed effects model (if I2 = 50%). Although the included studies reported inconclusive results, the majority supported a protective effect of odd-chain and an adverse impact of even-chain SFAs. Meta-analysis showed that the per standard deviation (SD) increase in odd-chain SFAs was associated with a reduced risk of incident T2D (C15:0: 0.86, 0.76-0.98; C17:0: 0.76, 0.59-0.97), while a per SD increase in one even-chain SFA was associated with an increased risk of incident T2D (C14:0: 1.13, 1.09-1.18). No associations were found between other SFAs and incident T2D. In conclusion, our findings suggest an overall protective effect of odd-chain SFAs and the inconclusive impact of even- and very-long-chain SFAs on incident T2D. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2019 | |
dc.subject | Circulating | |
dc.subject | Incidence | |
dc.subject | Meta-analysis | |
dc.subject | Prospective cohort study | |
dc.subject | Saturated fatty acids | |
dc.subject | Systematic review | |
dc.subject | Type 2 diabetes | |
dc.type | Review | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.3390/nu11050998 | |
dc.description.sourcetitle | Nutrients | |
dc.description.volume | 11 | |
dc.description.issue | 5 | |
dc.description.page | 998 | |
Appears in Collections: | Staff Publications Elements |
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