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Title: The roles of microtubule-based transport at presynaptic nerve terminals
Authors: Yagensky, O
Dehaghi, TK
Chua, JJE 
Keywords: Dynein
intracellular trafficking
signaling pathways
Issue Date: 1-Jan-2016
Publisher: Frontiers Media SA
Citation: Yagensky, O, Dehaghi, TK, Chua, JJE (2016-01-01). The roles of microtubule-based transport at presynaptic nerve terminals. Frontiers in Synaptic Neuroscience 8 (FEB) : 3-. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins, often as vesicular packages, is mediated by motor complexes travelling along intracellular cytoskeletal networks. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by Dynein motors enables synapse-nuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other's functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function.
Source Title: Frontiers in Synaptic Neuroscience
ISSN: 16633563
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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