Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-019-41917-4
Title: Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension
Authors: Chua, J.
Chin, C.W.L. 
Tan, B.
Wong, S.H.
Devarajan, K.
Le, T.-T.
Ang, M.
Wong, T.Y.
Schmetterer, L.
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Chua, J., Chin, C.W.L., Tan, B., Wong, S.H., Devarajan, K., Le, T.-T., Ang, M., Wong, T.Y., Schmetterer, L. (2019). Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension. Scientific Reports 9 (1) : 5819. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-41917-4
Rights: Attribution 4.0 International
Abstract: We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to investigate the association of systemic risk factors with area (percentage), size (pixels) and number of choriocapillaris flow voids. Diabetes (? = 0.33; 95% CI, 0.02 to 0.63) and daytime systolic BP (? = ?0.13; 95% CI, ?0.24 to ?0.02) were associated with areas of flow voids. Age (? = 0.21; 95% CI, 0.06 to 0.36) and daytime diastolic BP (? = ?0.18; 95% CI, ?0.34 to ?0.02) were associated with size of flow voids. Age (? = ?21.21; 95% CI, ?31.79 to ?10.63) and nighttime diastolic BP (? = 13.89; 95% CI, 0.61 to 27.17) were associated with number of flow voids. Kidney parameters were not associated with any features of flow voids. In patients with hypertension, a higher BP appeared to increase blood flow in the choriocapillaris which needs to be considered when using the OCTA to study eye diseases in hypertensives. © 2019, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/213247
ISSN: 2045-2322
DOI: 10.1038/s41598-019-41917-4
Rights: Attribution 4.0 International
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