Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-019-41917-4
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dc.titleImpact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension
dc.contributor.authorChua, J.
dc.contributor.authorChin, C.W.L.
dc.contributor.authorTan, B.
dc.contributor.authorWong, S.H.
dc.contributor.authorDevarajan, K.
dc.contributor.authorLe, T.-T.
dc.contributor.authorAng, M.
dc.contributor.authorWong, T.Y.
dc.contributor.authorSchmetterer, L.
dc.date.accessioned2022-01-07T03:50:24Z
dc.date.available2022-01-07T03:50:24Z
dc.date.issued2019
dc.identifier.citationChua, J., Chin, C.W.L., Tan, B., Wong, S.H., Devarajan, K., Le, T.-T., Ang, M., Wong, T.Y., Schmetterer, L. (2019). Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension. Scientific Reports 9 (1) : 5819. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-41917-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/213247
dc.description.abstractWe investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to investigate the association of systemic risk factors with area (percentage), size (pixels) and number of choriocapillaris flow voids. Diabetes (? = 0.33; 95% CI, 0.02 to 0.63) and daytime systolic BP (? = ?0.13; 95% CI, ?0.24 to ?0.02) were associated with areas of flow voids. Age (? = 0.21; 95% CI, 0.06 to 0.36) and daytime diastolic BP (? = ?0.18; 95% CI, ?0.34 to ?0.02) were associated with size of flow voids. Age (? = ?21.21; 95% CI, ?31.79 to ?10.63) and nighttime diastolic BP (? = 13.89; 95% CI, 0.61 to 27.17) were associated with number of flow voids. Kidney parameters were not associated with any features of flow voids. In patients with hypertension, a higher BP appeared to increase blood flow in the choriocapillaris which needs to be considered when using the OCTA to study eye diseases in hypertensives. © 2019, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-019-41917-4
dc.description.sourcetitleScientific Reports
dc.description.volume9
dc.description.issue1
dc.description.page5819
dc.published.statePublished
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