Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.17-22069
Title: Biomechanical properties of bruch’s membrane-choroid complex and their influence on optic nerve head biomechanics
Authors: Wang, X. 
Teoh, C.K.G.
Chan, A.S.Y. 
Thangarajoo, S.
Jonas, J.B.
Girard, M.J.A. 
Keywords: Biomechanical properties
Bruch’s membrane
Finite element analysis
Intraocular pressure
Rupture pressure
Issue Date: 2018
Publisher: Association for Research in Vision and Ophthalmology Inc.
Citation: Wang, X., Teoh, C.K.G., Chan, A.S.Y., Thangarajoo, S., Jonas, J.B., Girard, M.J.A. (2018). Biomechanical properties of bruch’s membrane-choroid complex and their influence on optic nerve head biomechanics. Investigative Ophthalmology and Visual Science 59 (7) : 2808-2817. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.17-22069
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: PURPOSE. The purpose of this study was to measure the rupture pressure and the biomechanical properties of porcine Bruch’s membrane (BM)-choroid complex (BMCC) and the influences of BM on optic nerve head (ONH) tissues. METHODS. The biomechanical properties of BMCC were extracted through uniaxial tensile tests of 10 BMCC specimens from 10 porcine eyes; the rupture pressures of BMCC were measured through burst tests of 20 porcine eyes; and the influence of BM on IOP-induced ONH deformations were investigated using finite element (FE) analysis. RESULTS. Uniaxial experimental results showed that the average elastic (tangent) moduli of BMCC samples at 0% and 5% strain were 1.60 ± 0.81 and 2.44 ± 1.02 MPa, respectively. Burst tests showed that, on average, BMCC could sustain an IOP of 82 mm Hg before rupture. FE simulation results predicted that, under elevated IOP, prelamina tissue strains increased with increasing BM stiffness. On the contrary, lamina cribrosa strains showed an opposite trend but the effects were small. CONCLUSIONS. BMCC stiffness is comparable or higher than those of other ocular tissues and can sustain a relatively high pressure before rupture. Additionally, BM may have a nonnegligible influence on IOP-induced ONH deformations. © 2018 The Authors.
Source Title: Investigative Ophthalmology and Visual Science
URI: https://scholarbank.nus.edu.sg/handle/10635/212547
ISSN: 0146-0404
DOI: 10.1167/iovs.17-22069
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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