Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.celrep.2019.10.067
Title: Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
Authors: Kliemann, D.
Adolphs, R.
Tyszka, J.M.
Fischl, B.
Yeo, B.T.T. 
Nair, R.
Dubois, J.
Paul, L.K.
Keywords: brain networks
fMRI
functional connectivity
hemispherectomy
plasticity
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Kliemann, D., Adolphs, R., Tyszka, J.M., Fischl, B., Yeo, B.T.T., Nair, R., Dubois, J., Paul, L.K. (2019). Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere. Cell Reports 29 (8) : 2398-24070000. ScholarBank@NUS Repository. https://doi.org/10.1016/j.celrep.2019.10.067
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy. Kliemann et al. present resting state neuroimaging data in six adults with childhood hemispherectomy, compared to controls. They find an intact functional organization into canonical networks, yet identify an increase in communication between networks—a possible characterization of functional reorganization in hemispherectomy. © 2019 The Authors
Source Title: Cell Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/212422
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.10.067
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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