Please use this identifier to cite or link to this item:
Title: Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
Authors: Kliemann, D.
Adolphs, R.
Tyszka, J.M.
Fischl, B.
Yeo, B.T.T. 
Nair, R.
Dubois, J.
Paul, L.K.
Keywords: brain networks
functional connectivity
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Kliemann, D., Adolphs, R., Tyszka, J.M., Fischl, B., Yeo, B.T.T., Nair, R., Dubois, J., Paul, L.K. (2019). Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere. Cell Reports 29 (8) : 2398-24070000. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy. Kliemann et al. present resting state neuroimaging data in six adults with childhood hemispherectomy, compared to controls. They find an intact functional organization into canonical networks, yet identify an increase in communication between networks—a possible characterization of functional reorganization in hemispherectomy. © 2019 The Authors
Source Title: Cell Reports
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.10.067
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1016_j_celrep_2019_10_067.pdf2.35 MBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons