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|Title:||Vinorelbine-Cyclophosphamide compared to cyclophosphamide in peripheral blood stem cell mobilization for multiple myeloma||Authors:||de Mel, S.
Yelly, Department of Haematology-Oncology National University Cancer Institute, National University Health System, Singapore.
|Issue Date:||2018||Publisher:||King Faisal Specialist Hospital and Research Centre||Citation:||de Mel, S., Chen, Y., Lin, A., Soh, T.G., Ooi, M., Yap, E.S., Donato, L.K.S., Halim, N.A.A., Mah, J., Lim, K., Poon, L.M., Tan, B., Yelly, Department of Haematology-Oncology National University Cancer Institute, National University Health System, Singapore., Lim, H.L., Koh, L.P., Tai, B.C., Chen, Z., Chng, W.J., Gopalakrishnan, S.K., Tan, L.K. (2018). Vinorelbine-Cyclophosphamide compared to cyclophosphamide in peripheral blood stem cell mobilization for multiple myeloma. Hematology/ Oncology and Stem Cell Therapy 11 (4) : 225-232. ScholarBank@NUS Repository. https://doi.org/10.1016/j.hemonc.2018.04.001||Rights:||Attribution-NonCommercial-NoDerivatives 4.0 International||Abstract:||Background: High dose Cyclophosphamide (Cy) and Vinorelbine Cyclophosphamide (Vino-Cy) are stem cell (SC) mobilisation options for patients with multiple myeloma (MM). We present a comparison of mobilisation outcomes using these regimens. Patients and methods: Vino-Cy patients received Vinorelbine 25 mg/m2 on day 1, cyclophosphamide 1500 mg/m2 on day 2, and pegylated GCSF on day 4 or GCSF 10 mcg/kg/day from day 4 onwards. Cy patients were given cyclophosphamide 4000 mg/m2 on day 1 and GCSF10 mcg/kg/day from day 5 onwards. The target CD34 + SC collection was 5 × 106 per kg/BW. Results: 149 patients were included. SC collection was lower in the Vino-Cy group (8.20 × 106/Kg BW) compared to the Cy group (11.43 × 106/Kg BW), with adjusted geometric mean ratio of 0.59 (95% CI 0.41 to 0.86, p = 0.006). Time taken to achieve an adequate PB SC count was shorter for Vino-Cy (9 ± 1 day compared to 12 ± 2 days for Cy, adjusted absolute mean difference ?3.95, 95% CI ?4.85 to ?3.06, P <.001). Mobilisation related toxicities (in particular, neutropaenic fever) were greater for Cy. Conclusion: Vino-Cy is a potential alternative to Cy given the need for effective mobilisation protocols with acceptable toxicity. © 2018 King Faisal Specialist Hospital & Research Centre||Source Title:||Hematology/ Oncology and Stem Cell Therapy||URI:||https://scholarbank.nus.edu.sg/handle/10635/212374||ISSN:||16583876||DOI:||10.1016/j.hemonc.2018.04.001||Rights:||Attribution-NonCommercial-NoDerivatives 4.0 International|
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