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Title: Quantum biological tunnel junction for electron transfer imaging in live cells
Authors: Xin, H. 
Sim, W.J. 
Namgung, B. 
Choi, Y.
Li, B.
Lee, L.P. 
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Xin, H., Sim, W.J., Namgung, B., Choi, Y., Li, B., Lee, L.P. (2019). Quantum biological tunnel junction for electron transfer imaging in live cells. Nature Communications 10 (1) : 3245. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Quantum biological electron transfer (ET) essentially involves in virtually all important biological processes such as photosynthesis, cellular respiration, DNA repair, cellular homeostasis, and cell death. However, there is no real-time imaging method to capture biological electron tunnelling in live cells to date. Here, we report a quantum biological electron tunnelling (QBET) junction and its application in real-time optical detection of QBET and the dynamics of ET in mitochondrial cytochrome c during cell life and death process. QBET junctions permit to see the behaviours of electron tunnelling through barrier molecules with different barrier widths. Using QBET spectroscopy, we optically capture real-time ET in cytochrome c redox dynamics during cellular apoptosis and necrosis in living cells. The non-invasive real-time QBET spectroscopic imaging of ET in live cell open a new era in life sciences and medicine by providing a way to capture spatiotemporal ET dynamics and to reveal the quantum biological mechanisms. © 2019, The Author(s).
Source Title: Nature Communications
ISSN: 20411723
DOI: 10.1038/s41467-019-11212-x
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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