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https://doi.org/10.1038/s41467-019-11212-x
DC Field | Value | |
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dc.title | Quantum biological tunnel junction for electron transfer imaging in live cells | |
dc.contributor.author | Xin, H. | |
dc.contributor.author | Sim, W.J. | |
dc.contributor.author | Namgung, B. | |
dc.contributor.author | Choi, Y. | |
dc.contributor.author | Li, B. | |
dc.contributor.author | Lee, L.P. | |
dc.date.accessioned | 2021-12-29T04:05:54Z | |
dc.date.available | 2021-12-29T04:05:54Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Xin, H., Sim, W.J., Namgung, B., Choi, Y., Li, B., Lee, L.P. (2019). Quantum biological tunnel junction for electron transfer imaging in live cells. Nature Communications 10 (1) : 3245. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-11212-x | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/212242 | |
dc.description.abstract | Quantum biological electron transfer (ET) essentially involves in virtually all important biological processes such as photosynthesis, cellular respiration, DNA repair, cellular homeostasis, and cell death. However, there is no real-time imaging method to capture biological electron tunnelling in live cells to date. Here, we report a quantum biological electron tunnelling (QBET) junction and its application in real-time optical detection of QBET and the dynamics of ET in mitochondrial cytochrome c during cell life and death process. QBET junctions permit to see the behaviours of electron tunnelling through barrier molecules with different barrier widths. Using QBET spectroscopy, we optically capture real-time ET in cytochrome c redox dynamics during cellular apoptosis and necrosis in living cells. The non-invasive real-time QBET spectroscopic imaging of ET in live cell open a new era in life sciences and medicine by providing a way to capture spatiotemporal ET dynamics and to reveal the quantum biological mechanisms. © 2019, The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2019 | |
dc.type | Article | |
dc.contributor.department | BIOMED INST FOR GLOBAL HEALTH RES & TECH | |
dc.contributor.department | DEPT OF BIOMEDICAL ENGINEERING | |
dc.description.doi | 10.1038/s41467-019-11212-x | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.description.page | 3245 | |
Appears in Collections: | Staff Publications Elements |
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