Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-11212-x
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dc.titleQuantum biological tunnel junction for electron transfer imaging in live cells
dc.contributor.authorXin, H.
dc.contributor.authorSim, W.J.
dc.contributor.authorNamgung, B.
dc.contributor.authorChoi, Y.
dc.contributor.authorLi, B.
dc.contributor.authorLee, L.P.
dc.date.accessioned2021-12-29T04:05:54Z
dc.date.available2021-12-29T04:05:54Z
dc.date.issued2019
dc.identifier.citationXin, H., Sim, W.J., Namgung, B., Choi, Y., Li, B., Lee, L.P. (2019). Quantum biological tunnel junction for electron transfer imaging in live cells. Nature Communications 10 (1) : 3245. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-11212-x
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212242
dc.description.abstractQuantum biological electron transfer (ET) essentially involves in virtually all important biological processes such as photosynthesis, cellular respiration, DNA repair, cellular homeostasis, and cell death. However, there is no real-time imaging method to capture biological electron tunnelling in live cells to date. Here, we report a quantum biological electron tunnelling (QBET) junction and its application in real-time optical detection of QBET and the dynamics of ET in mitochondrial cytochrome c during cell life and death process. QBET junctions permit to see the behaviours of electron tunnelling through barrier molecules with different barrier widths. Using QBET spectroscopy, we optically capture real-time ET in cytochrome c redox dynamics during cellular apoptosis and necrosis in living cells. The non-invasive real-time QBET spectroscopic imaging of ET in live cell open a new era in life sciences and medicine by providing a way to capture spatiotemporal ET dynamics and to reveal the quantum biological mechanisms. © 2019, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentBIOMED INST FOR GLOBAL HEALTH RES & TECH
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1038/s41467-019-11212-x
dc.description.sourcetitleNature Communications
dc.description.volume10
dc.description.issue1
dc.description.page3245
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