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|Title:||A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study||Authors:||Tan, K.M.
|Issue Date:||2019||Publisher:||Nature Publishing Group||Citation:||Tan, K.M., Chia, B., Lim, J.Q., Khoo, L.P., Cheng, C.L., Tan, L., Poon, E., Somasundaram, N., Farid, M., Tang, T.P.L., Tao, M., Cheah, D.M.Z., Laurensia, Y., Pang, J.W.L., Song, T., Tan, J., Huang, D., Kim, S.J., Kim, W.S., Ong, C.K., Lim, S.T., Chan, J.Y. (2019). A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study. Scientific Reports 9 (1) : 14961. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-51522-0||Rights:||Attribution 4.0 International||Abstract:||Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with NKTL. Therefore, we conducted a retrospective review of 178 patients with biopsy-proven NKTL from the National Cancer Centre Singapore and Samsung Medical Center, South Korea. Using receiver operating curve analysis, an optimal cut-off for high NLR (>3.5) in predicting overall survival (OS) was derived. Survival analysis was performed using the Kaplan-Meier method and multivariable Cox proportional regression. In patients with high NLR, estimated 5-year OS was 25% compared to 53% in those with low NLR. In multivariable analysis, high NLR, in addition to age ?60 years, presence of B-symptoms and stage III/IV at diagnosis, was independently correlated with worse OS (HR 2.08; 95% CI 1.36 to 3.18; p = 0.0008) and progression-free survival (HR 1.66; 95% CI 1.11 to 2.46; p = 0.0128). A new prognostic index (NABS score) derived from these factors stratified patients into low (0), low-intermediate (1), high-intermediate (2) and high (3–4) risk subgroups, which were associated with 5-year OS of 76.5%, 55.7%, 29.2% and 0% respectively. In conclusion, high NLR is an independent prognostic marker and the NABS model can be used to risk-stratify NKTL patients. © 2019, The Author(s).||Source Title:||Scientific Reports||URI:||https://scholarbank.nus.edu.sg/handle/10635/210913||ISSN:||20452322||DOI:||10.1038/s41598-019-51522-0||Rights:||Attribution 4.0 International|
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