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Title: A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study
Authors: Tan, K.M.
Chia, B.
Lim, J.Q.
Khoo, L.P.
Cheng, C.L.
Tan, L.
Poon, E.
Somasundaram, N.
Farid, M.
Tang, T.P.L.
Tao, M.
Cheah, D.M.Z.
Laurensia, Y.
Pang, J.W.L.
Song, T.
Tan, J.
Huang, D.
Kim, S.J.
Kim, W.S.
Ong, C.K. 
Lim, S.T. 
Chan, J.Y.
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Tan, K.M., Chia, B., Lim, J.Q., Khoo, L.P., Cheng, C.L., Tan, L., Poon, E., Somasundaram, N., Farid, M., Tang, T.P.L., Tao, M., Cheah, D.M.Z., Laurensia, Y., Pang, J.W.L., Song, T., Tan, J., Huang, D., Kim, S.J., Kim, W.S., Ong, C.K., Lim, S.T., Chan, J.Y. (2019). A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study. Scientific Reports 9 (1) : 14961. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with NKTL. Therefore, we conducted a retrospective review of 178 patients with biopsy-proven NKTL from the National Cancer Centre Singapore and Samsung Medical Center, South Korea. Using receiver operating curve analysis, an optimal cut-off for high NLR (>3.5) in predicting overall survival (OS) was derived. Survival analysis was performed using the Kaplan-Meier method and multivariable Cox proportional regression. In patients with high NLR, estimated 5-year OS was 25% compared to 53% in those with low NLR. In multivariable analysis, high NLR, in addition to age ?60 years, presence of B-symptoms and stage III/IV at diagnosis, was independently correlated with worse OS (HR 2.08; 95% CI 1.36 to 3.18; p = 0.0008) and progression-free survival (HR 1.66; 95% CI 1.11 to 2.46; p = 0.0128). A new prognostic index (NABS score) derived from these factors stratified patients into low (0), low-intermediate (1), high-intermediate (2) and high (3–4) risk subgroups, which were associated with 5-year OS of 76.5%, 55.7%, 29.2% and 0% respectively. In conclusion, high NLR is an independent prognostic marker and the NABS model can be used to risk-stratify NKTL patients. © 2019, The Author(s).
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-019-51522-0
Rights: Attribution 4.0 International
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