Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.aao0773
Title: Nanometer-precision linear sorting with synchronized optofluidic dual barriers
Authors: Shi, Y.
Xiong, S.
Chin, L.K.
Zhang, J.
Ser, W.
Wu, J.
Chen, T.
Yang, Z.
Hao, Y.
Liedberg, B.
Yap, P.H.
Tsai, D.P.
Qiu, C.-W. 
Liu, A.Q.
Issue Date: 2018
Publisher: American Association for the Advancement of Science
Citation: Shi, Y., Xiong, S., Chin, L.K., Zhang, J., Ser, W., Wu, J., Chen, T., Yang, Z., Hao, Y., Liedberg, B., Yap, P.H., Tsai, D.P., Qiu, C.-W., Liu, A.Q. (2018). Nanometer-precision linear sorting with synchronized optofluidic dual barriers. Science Advances 4 (1) : eaao0773. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.aao0773
Rights: Attribution-NonCommercial 4.0 International
Abstract: The past two decades have witnessed the revolutionary development of optical trapping of nanoparticles, most of which deal with trapping stiffness larger than 10−8N/m. In this conventional regime, however, it remains a formidable challenge to sort out sub–50-nm nanoparticles with single-nanometer precision, isolating us from a rich flatland with advanced applications of micromanipulation. With an insightfully established roadmap of damping, the synchronization between optical force and flow drag force can be coordinated to attempt the loosely overdamped realm (stiffness, 10− 10to 10− 8N/m), which has been challenging. This paper intuitively demonstrates the remarkable functionality to sort out single gold nanoparticles with radii ranging from 30 to 50 nm, as well as 100- and 150-nm polystyrene nanoparticles, with single nanometer precision. The quasi-Bessel optical profile and the loosely overdamped potential wells in the microchannel enable those aforementioned nanoparticles to be separated, positioned, and microscopically oscillated. This work reveals an unprecedentedly meaningful damping scenario that enriches our fundamental understanding of particle kinetics in intriguing optical systems, and offers new opportunities for tumor targeting, intracellular imaging, and sorting small particles such as viruses and DNA. Copyright © 2018 The Authors.
Source Title: Science Advances
URI: https://scholarbank.nus.edu.sg/handle/10635/210910
ISSN: 23752548
DOI: 10.1126/sciadv.aao0773
Rights: Attribution-NonCommercial 4.0 International
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