Please use this identifier to cite or link to this item: https://doi.org/10.3390/brainsci9090238
Title: Targeting the mitochondrial pyruvate carrier for neuroprotection
Authors: Tang, B.L. 
Keywords: Excitotoxicity
Mitochondrial pyruvate carrier (MPC)
Neuroprotection
Neurotoxicity
Warburg effect
Issue Date: 2019
Publisher: MDPI AG
Citation: Tang, B.L. (2019). Targeting the mitochondrial pyruvate carrier for neuroprotection. Brain Sciences 9 (9) : 238. ScholarBank@NUS Repository. https://doi.org/10.3390/brainsci9090238
Rights: Attribution 4.0 International
Abstract: The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. © 2019 by the author. Licensee MDPI, Basel, Switzerland.
Source Title: Brain Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/210743
ISSN: 20763425
DOI: 10.3390/brainsci9090238
Rights: Attribution 4.0 International
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