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https://doi.org/10.3390/brainsci9090238
Title: | Targeting the mitochondrial pyruvate carrier for neuroprotection | Authors: | Tang, B.L. | Keywords: | Excitotoxicity Mitochondrial pyruvate carrier (MPC) Neuroprotection Neurotoxicity Warburg effect |
Issue Date: | 2019 | Publisher: | MDPI AG | Citation: | Tang, B.L. (2019). Targeting the mitochondrial pyruvate carrier for neuroprotection. Brain Sciences 9 (9) : 238. ScholarBank@NUS Repository. https://doi.org/10.3390/brainsci9090238 | Rights: | Attribution 4.0 International | Abstract: | The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. © 2019 by the author. Licensee MDPI, Basel, Switzerland. | Source Title: | Brain Sciences | URI: | https://scholarbank.nus.edu.sg/handle/10635/210743 | ISSN: | 20763425 | DOI: | 10.3390/brainsci9090238 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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