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https://doi.org/10.1038/s41598-019-43364-7
Title: | IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice | Authors: | Zhang, S.R. Nold, M.F. Tang, S.-C. Bui, C.B. Nold, C.A. Arumugam, T.V. Drummond, G.R. Sobey, C.G. Kim, H.A. |
Issue Date: | 2019 | Publisher: | Nature Publishing Group | Citation: | Zhang, S.R., Nold, M.F., Tang, S.-C., Bui, C.B., Nold, C.A., Arumugam, T.V., Drummond, G.R., Sobey, C.G., Kim, H.A. (2019). IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice. Scientific Reports 9 (1) : 6922. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-43364-7 | Rights: | Attribution 4.0 International | Abstract: | Post-stroke inflammation may contribute to secondary brain injury and systemic immunosuppression. Interleukin(IL)-37 is an immunosuppressive cytokine belonging to the IL-1 superfamily with no mouse homologue yet identified, the effects of which have not been studied in stroke. Here we report: (1) the effect of ischemic stroke on circulating IL-37 in humans; and (2) the effect of IL-37 on stroke outcome measures in mice transgenic for human IL-37 (IL-37tg). We found that in the first 3 days after ischemic stroke in 55 patients, the plasma abundance of IL-37 was ~2-fold higher than in 24 controls. In IL-37tg mice, cerebral ischemia-reperfusion resulted in marked increases in plasma IL-37 (~9-fold) and brain IL-37 mRNA (~7,000-fold) at 24 h compared with sham-operated IL-37tg mice. Further, compared with wild-type (WT) mice subjected to cerebral ischemia-reperfusion, IL-37tg mice exhibited less severe locomotor deficit, smaller cerebral infarcts and reduced bacterial lung infection. In the ischemic hemisphere, there were 60% fewer pro-inflammatory microglia-macrophages and up to 4-fold higher expression of anti-inflammatory markers in IL-37tg compared to WT mice. Our data show that IL-37 expression is increased following ischemic stroke in humans and IL-37tg mice, and may exert protective effects by modulating post-stroke inflammation in the brain and periphery. © 2019, The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/210705 | ISSN: | 20452322 | DOI: | 10.1038/s41598-019-43364-7 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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