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Title: Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation
Authors: Ghaeminia, M. 
Rajkumar, R. 
Koh, H.-L. 
Dawe, G.S. 
Tan, C.H. 
Keywords: ginsenoside Rg1
long-term potentiation
medical prefrontal cortex
single unit
Issue Date: 2018
Publisher: Elsevier B.V.
Citation: Ghaeminia, M., Rajkumar, R., Koh, H.-L., Dawe, G.S., Tan, C.H. (2018). Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation. Journal of Ginseng Research 42 (3) : 298-303. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal–medial prefrontal cortical (HP–mPFC) pathway were investigated in male Sprague–Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP–mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP–mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1. © 2017
Source Title: Journal of Ginseng Research
ISSN: 1226-8453
DOI: 10.1016/j.jgr.2017.03.010
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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