Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jgr.2017.03.010
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dc.titleGinsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation
dc.contributor.authorGhaeminia, M.
dc.contributor.authorRajkumar, R.
dc.contributor.authorKoh, H.-L.
dc.contributor.authorDawe, G.S.
dc.contributor.authorTan, C.H.
dc.date.accessioned2021-12-09T05:01:24Z
dc.date.available2021-12-09T05:01:24Z
dc.date.issued2018
dc.identifier.citationGhaeminia, M., Rajkumar, R., Koh, H.-L., Dawe, G.S., Tan, C.H. (2018). Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation. Journal of Ginseng Research 42 (3) : 298-303. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jgr.2017.03.010
dc.identifier.issn1226-8453
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/210097
dc.description.abstractBackground: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal–medial prefrontal cortical (HP–mPFC) pathway were investigated in male Sprague–Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP–mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP–mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1. © 2017
dc.publisherElsevier B.V.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2018
dc.subjectginsenoside Rg1
dc.subjecthippocampus
dc.subjectlong-term potentiation
dc.subjectmedical prefrontal cortex
dc.subjectsingle unit
dc.typeArticle
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentOFFICE OF SAFETY, HEALTH AND ENVIRONMENT
dc.contributor.departmentDEPT OF PHARMACY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.jgr.2017.03.010
dc.description.sourcetitleJournal of Ginseng Research
dc.description.volume42
dc.description.issue3
dc.description.page298-303
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