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https://doi.org/10.1016/j.jgr.2017.03.010
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dc.title | Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation | |
dc.contributor.author | Ghaeminia, M. | |
dc.contributor.author | Rajkumar, R. | |
dc.contributor.author | Koh, H.-L. | |
dc.contributor.author | Dawe, G.S. | |
dc.contributor.author | Tan, C.H. | |
dc.date.accessioned | 2021-12-09T05:01:24Z | |
dc.date.available | 2021-12-09T05:01:24Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Ghaeminia, M., Rajkumar, R., Koh, H.-L., Dawe, G.S., Tan, C.H. (2018). Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation. Journal of Ginseng Research 42 (3) : 298-303. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jgr.2017.03.010 | |
dc.identifier.issn | 1226-8453 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/210097 | |
dc.description.abstract | Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal–medial prefrontal cortical (HP–mPFC) pathway were investigated in male Sprague–Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP–mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP–mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1. © 2017 | |
dc.publisher | Elsevier B.V. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Scopus OA2018 | |
dc.subject | ginsenoside Rg1 | |
dc.subject | hippocampus | |
dc.subject | long-term potentiation | |
dc.subject | medical prefrontal cortex | |
dc.subject | single unit | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | OFFICE OF SAFETY, HEALTH AND ENVIRONMENT | |
dc.contributor.department | PHARMACY | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1016/j.jgr.2017.03.010 | |
dc.description.sourcetitle | Journal of Ginseng Research | |
dc.description.volume | 42 | |
dc.description.issue | 3 | |
dc.description.page | 298-303 | |
Appears in Collections: | Staff Publications Elements |
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