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Title: Targeting immune cells for cancer therapy
Authors: Gun, S.Y.
Lee, S.W.L. 
Sieow, J.L.
Wong, S.C. 
Keywords: Cancer
Immune checkpoint
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Gun, S.Y., Lee, S.W.L., Sieow, J.L., Wong, S.C. (2019). Targeting immune cells for cancer therapy. Redox Biology 25 : 101174. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Recent years have seen a renaissance in the research linking inflammation and cancer with immune cells playing a central role in smouldering inflammation in the tumor microenvironment. Diverse immune cell types infiltrate the tumor microenvironment, and the dynamic tumor-immune cell interplay gives rise to a rich milieu of cytokines and growth factors. Fundamentally, this intricate cross-talk creates the conducive condition for tumor cell proliferation, survival and metastasis. Interestingly, the prominent impact of immune cells is expounded in their contrary pro-tumoral role, as well as their potential anti-cancer cellular weaponry. The latter is known as immunotherapy, a concept born out of evidence that tumors are susceptible to immune defence and that by manipulating the immune system, tumor growth can be successfully restrained. Naturally, a deeper understanding of the multifaceted roles of various immune cell types thus contributes toward developing innovative anti-cancer strategies. Therefore, in this review we first outline the roles played by the major immune cell types, such as macrophages, neutrophils, natural killer cells, T cells and B cells. We then explain the recently-explored strategies of immunomodulation and discuss some important approaches via an immunology perspective. © 2019 The Authors
Source Title: Redox Biology
ISSN: 2213-2317
DOI: 10.1016/j.redox.2019.101174
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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