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Title: Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions
Authors: Bai, J.
Kwok, W.C. 
Thiery, J.-P.
Keywords: Cancer invasion and metastasis
Epithelial-mesenchymal transition
Stromal cells
Traditional Chinese Medicine
Issue Date: 2019
Publisher: BioMed Central Ltd.
Citation: Bai, J., Kwok, W.C., Thiery, J.-P. (2019). Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions. Chinese Medicine (United Kingdom) 14 (1) : 34. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Epithelial-mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effect physiological, sometimes pathological outcomes. Traditional Chinese Medicine (TCM) has been clinically prescribed for thousands of years and recent studies have found that TCM therapies can participate in EMT regulation. In this review, the historical discovery of EMT will be introduced, followed by a brief overview of its major roles in development and diseases. The second section will focus on EMT in organ fibrosis and tissue regeneration. The third section discusses EMT-induced cancer metastasis, and details how EMT contribute to distant dissemination. Finally, new EMT players are described, namely microRNA, epigenetic modifications, and alternative splicing. TCM drugs that affect EMT proven through an evidence-based research approach will be presented in each section. © 2019 The Author(s).
Source Title: Chinese Medicine (United Kingdom)
ISSN: 1749-8546
DOI: 10.1186/s13020-019-0257-6
Rights: Attribution 4.0 International
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