Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13020-019-0257-6
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dc.titleTraditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions
dc.contributor.authorBai, J.
dc.contributor.authorKwok, W.C.
dc.contributor.authorThiery, J.-P.
dc.date.accessioned2021-12-09T03:01:47Z
dc.date.available2021-12-09T03:01:47Z
dc.date.issued2019
dc.identifier.citationBai, J., Kwok, W.C., Thiery, J.-P. (2019). Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions. Chinese Medicine (United Kingdom) 14 (1) : 34. ScholarBank@NUS Repository. https://doi.org/10.1186/s13020-019-0257-6
dc.identifier.issn1749-8546
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/209936
dc.description.abstractEpithelial-mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effect physiological, sometimes pathological outcomes. Traditional Chinese Medicine (TCM) has been clinically prescribed for thousands of years and recent studies have found that TCM therapies can participate in EMT regulation. In this review, the historical discovery of EMT will be introduced, followed by a brief overview of its major roles in development and diseases. The second section will focus on EMT in organ fibrosis and tissue regeneration. The third section discusses EMT-induced cancer metastasis, and details how EMT contribute to distant dissemination. Finally, new EMT players are described, namely microRNA, epigenetic modifications, and alternative splicing. TCM drugs that affect EMT proven through an evidence-based research approach will be presented in each section. © 2019 The Author(s).
dc.publisherBioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectCancer invasion and metastasis
dc.subjectEpithelial-mesenchymal transition
dc.subjectFibrosis
dc.subjectStromal cells
dc.subjectTraditional Chinese Medicine
dc.subjectWound-repair
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1186/s13020-019-0257-6
dc.description.sourcetitleChinese Medicine (United Kingdom)
dc.description.volume14
dc.description.issue1
dc.description.page34
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