Please use this identifier to cite or link to this item: https://doi.org/10.3389/fimmu.2019.01227
Title: Vaccination with sporozoites: Models and correlates of protection
Authors: Goh, Y.S.
McGuire, D.
Rénia, L. 
Keywords: Correlates
Malaria
Models
Plasmodium falciparum
Protection
Sporozoites
Vaccine
Issue Date: 2019
Publisher: Frontiers Media S.A.
Citation: Goh, Y.S., McGuire, D., Rénia, L. (2019). Vaccination with sporozoites: Models and correlates of protection. Frontiers in Immunology 10 : 1227. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2019.01227
Rights: Attribution 4.0 International
Abstract: Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved. © 2019 Goh, McGuire and Rénia.
Source Title: Frontiers in Immunology
URI: https://scholarbank.nus.edu.sg/handle/10635/209627
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01227
Rights: Attribution 4.0 International
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