Please use this identifier to cite or link to this item: https://doi.org/10.1002/bjs5.50111
Title: Breast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings
Authors: Sinnadurai, S
Kwong, A
Hartman, M 
Tan, EY
Bhoo-Pathy, NT
Dahlui, M
See, MH
Yip, CH
Taib, NA
Bhoo-Pathy, N
Keywords: Science & Technology
Life Sciences & Biomedicine
Surgery
QUALITY-OF-LIFE
TRENDS
SURVIVAL
METAANALYSIS
MULTICENTER
MALAYSIA
THERAPY
CHINA
Issue Date: 1-Feb-2019
Publisher: JOHN WILEY & SONS LTD
Citation: Sinnadurai, S, Kwong, A, Hartman, M, Tan, EY, Bhoo-Pathy, NT, Dahlui, M, See, MH, Yip, CH, Taib, NA, Bhoo-Pathy, N (2019-02-01). Breast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings. BJS OPEN 3 (1) : 48-55. ScholarBank@NUS Repository. https://doi.org/10.1002/bjs5.50111
Abstract: Background: Mastectomy rates among women with early breast cancer in Asia have traditionally been high. This study assessed trends in the surgical management of young women with early-stage breast cancer in Asian settings. Survival in women treated with breast-conserving surgery (BCS; lumpectomy with adjuvant radiotherapy) and those undergoing mastectomy was compared. Methods: Young women (aged less than 50 years) newly diagnosed with stage I or II (T1-2 N0-1 M0) breast cancer in four hospitals in Malaysia, Singapore and Hong Kong in 1990-2012 were included. Overall survival (OS) was compared for patients treated by BCS and those who had a mastectomy. Propensity score analysis was used to account for differences in demographic, tumour and treatment characteristics between the groups. Results: Some 63·5 per cent of 3536 women underwent mastectomy. Over a 15-year period, only a modest increase in rates of BCS was observed. Although BCS was significantly associated with favourable prognostic features, OS was not significantly different for BCS and mastectomy; the 5-year OS rate was 94·9 (95 per cent c.i. 93·5 to 96·3) and 92·9 (91·7 to 94·1) per cent respectively. Inferences remained unchanged following propensity score analysis (hazard ratio for BCS versus mastectomy: 0·81, 95 per cent c.i. 0·64 to 1·03). Conclusion: The prevalence of young women with breast cancer treated by mastectomy remains high in Asian countries. Patients treated with BCS appear to survive as well as those undergoing mastectomy.
Source Title: BJS OPEN
URI: https://scholarbank.nus.edu.sg/handle/10635/208270
ISSN: 24749842
DOI: 10.1002/bjs5.50111
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