Please use this identifier to cite or link to this item: https://doi.org/10.1002/bjs5.50111
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dc.titleBreast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings
dc.contributor.authorSinnadurai, S
dc.contributor.authorKwong, A
dc.contributor.authorHartman, M
dc.contributor.authorTan, EY
dc.contributor.authorBhoo-Pathy, NT
dc.contributor.authorDahlui, M
dc.contributor.authorSee, MH
dc.contributor.authorYip, CH
dc.contributor.authorTaib, NA
dc.contributor.authorBhoo-Pathy, N
dc.date.accessioned2021-11-26T04:08:04Z
dc.date.available2021-11-26T04:08:04Z
dc.date.issued2019-02-01
dc.identifier.citationSinnadurai, S, Kwong, A, Hartman, M, Tan, EY, Bhoo-Pathy, NT, Dahlui, M, See, MH, Yip, CH, Taib, NA, Bhoo-Pathy, N (2019-02-01). Breast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings. BJS OPEN 3 (1) : 48-55. ScholarBank@NUS Repository. https://doi.org/10.1002/bjs5.50111
dc.identifier.issn24749842
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/208270
dc.description.abstractBackground: Mastectomy rates among women with early breast cancer in Asia have traditionally been high. This study assessed trends in the surgical management of young women with early-stage breast cancer in Asian settings. Survival in women treated with breast-conserving surgery (BCS; lumpectomy with adjuvant radiotherapy) and those undergoing mastectomy was compared. Methods: Young women (aged less than 50 years) newly diagnosed with stage I or II (T1-2 N0-1 M0) breast cancer in four hospitals in Malaysia, Singapore and Hong Kong in 1990-2012 were included. Overall survival (OS) was compared for patients treated by BCS and those who had a mastectomy. Propensity score analysis was used to account for differences in demographic, tumour and treatment characteristics between the groups. Results: Some 63·5 per cent of 3536 women underwent mastectomy. Over a 15-year period, only a modest increase in rates of BCS was observed. Although BCS was significantly associated with favourable prognostic features, OS was not significantly different for BCS and mastectomy; the 5-year OS rate was 94·9 (95 per cent c.i. 93·5 to 96·3) and 92·9 (91·7 to 94·1) per cent respectively. Inferences remained unchanged following propensity score analysis (hazard ratio for BCS versus mastectomy: 0·81, 95 per cent c.i. 0·64 to 1·03). Conclusion: The prevalence of young women with breast cancer treated by mastectomy remains high in Asian countries. Patients treated with BCS appear to survive as well as those undergoing mastectomy.
dc.language.isoen
dc.publisherJOHN WILEY & SONS LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectSurgery
dc.subjectQUALITY-OF-LIFE
dc.subjectTRENDS
dc.subjectSURVIVAL
dc.subjectMETAANALYSIS
dc.subjectMULTICENTER
dc.subjectMALAYSIA
dc.subjectTHERAPY
dc.subjectCHINA
dc.typeArticle
dc.date.updated2021-11-25T16:26:22Z
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.description.doi10.1002/bjs5.50111
dc.description.sourcetitleBJS OPEN
dc.description.volume3
dc.description.issue1
dc.description.page48-55
dc.published.statePublished
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