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https://doi.org/10.3390/cancers13061308
Title: | Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study | Authors: | Lee, Pei Yi Oen, Kellynn Qi Xuan Lim, Grace Rui Si JUANDA LEO HARTONO MARK DHINESH MUTHIAH Huang, Daniel Q Teo, Felicia Su Wei LI YUNKAI ANDREW Mak, A. Chandran, Nisha Suyien CHRIS TAN LIXIAN Yang, Peiling Tai, E.S. Ng, Kay Wei Ping JOY VIJAYAN Chan, Yee Cheun TAN LI LING LEE BENG HUAT, MARTIN Chua, Horng Ruey HONG WEI ZHEN YAP ENG SOO Lim, Dawn K YUEN YEW SEN Chan, Y.H. FOLEFAC AMINKENG Wong, Alvin Seng Cheong Huang, Yiqing TAY SEN HEE |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology neutrophil-to-lymphocyte ratio immunotherapy immune-related adverse events survival |
Issue Date: | 1-Mar-2021 | Publisher: | MDPI | Citation: | Lee, Pei Yi, Oen, Kellynn Qi Xuan, Lim, Grace Rui Si, JUANDA LEO HARTONO, MARK DHINESH MUTHIAH, Huang, Daniel Q, Teo, Felicia Su Wei, LI YUNKAI ANDREW, Mak, A., Chandran, Nisha Suyien, CHRIS TAN LIXIAN, Yang, Peiling, Tai, E.S., Ng, Kay Wei Ping, JOY VIJAYAN, Chan, Yee Cheun, TAN LI LING, LEE BENG HUAT, MARTIN, Chua, Horng Ruey, HONG WEI ZHEN, YAP ENG SOO, Lim, Dawn K, YUEN YEW SEN, Chan, Y.H., FOLEFAC AMINKENG, Wong, Alvin Seng Cheong, Huang, Yiqing, TAY SEN HEE (2021-03-01). Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study. CANCERS 13 (6). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13061308 | Abstract: | The utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) utility in predicting immune-related adverse events (irAEs) and survival have not been well studied in the context of treatment with immune checkpoint inhibitors (ICIs). We performed a case-control study of cancer patients who received at least one dose of ICI in a tertiary hospital. We examined NLR and PLR in irAE cases and controls. Logistic and Cox regression models were used to identify independent risk factors for irAEs, progression-free survival (PFS), and overall survival (OS). The study included 91 patients with irAEs and 56 controls. Multiple logistic regression showed that NLR < 3 at baseline was associated with higher occurrence of irAEs. Multivariate Cox regression showed that development of irAEs and reduction in NLR from baseline to week 6 were associated with longer PFS. Higher NLR values at baseline and/or week 6 were independently associated with shorter OS. A reduction in NLR from baseline to week 6 was associated with longer OS. In this study of cancer patients treated with ICIs, NLR has a bidirectional relationship with adverse outcomes. Lower NLR was associated with increased occurrence of irAEs while higher NLR values were associated with worse clinical outcomes. | Source Title: | CANCERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/208036 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers13061308 |
Appears in Collections: | Staff Publications Elements |
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