Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers13061308
Title: Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study
Authors: Lee, Pei Yi
Oen, Kellynn Qi Xuan
Lim, Grace Rui Si
JUANDA LEO HARTONO 
MARK DHINESH MUTHIAH 
Huang, Daniel Q
Teo, Felicia Su Wei
LI YUNKAI ANDREW 
Mak, A. 
Chandran, Nisha Suyien
CHRIS TAN LIXIAN 
Yang, Peiling
Tai, E.S. 
Ng, Kay Wei Ping
JOY VIJAYAN 
Chan, Yee Cheun
TAN LI LING 
LEE BENG HUAT, MARTIN 
Chua, Horng Ruey
HONG WEI ZHEN 
YAP ENG SOO 
Lim, Dawn K
YUEN YEW SEN 
Chan, Y.H. 
FOLEFAC AMINKENG 
Wong, Alvin Seng Cheong
Huang, Yiqing
TAY SEN HEE 
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
neutrophil-to-lymphocyte ratio
immunotherapy
immune-related adverse events
survival
Issue Date: 1-Mar-2021
Publisher: MDPI
Citation: Lee, Pei Yi, Oen, Kellynn Qi Xuan, Lim, Grace Rui Si, JUANDA LEO HARTONO, MARK DHINESH MUTHIAH, Huang, Daniel Q, Teo, Felicia Su Wei, LI YUNKAI ANDREW, Mak, A., Chandran, Nisha Suyien, CHRIS TAN LIXIAN, Yang, Peiling, Tai, E.S., Ng, Kay Wei Ping, JOY VIJAYAN, Chan, Yee Cheun, TAN LI LING, LEE BENG HUAT, MARTIN, Chua, Horng Ruey, HONG WEI ZHEN, YAP ENG SOO, Lim, Dawn K, YUEN YEW SEN, Chan, Y.H., FOLEFAC AMINKENG, Wong, Alvin Seng Cheong, Huang, Yiqing, TAY SEN HEE (2021-03-01). Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study. CANCERS 13 (6). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13061308
Abstract: The utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) utility in predicting immune-related adverse events (irAEs) and survival have not been well studied in the context of treatment with immune checkpoint inhibitors (ICIs). We performed a case-control study of cancer patients who received at least one dose of ICI in a tertiary hospital. We examined NLR and PLR in irAE cases and controls. Logistic and Cox regression models were used to identify independent risk factors for irAEs, progression-free survival (PFS), and overall survival (OS). The study included 91 patients with irAEs and 56 controls. Multiple logistic regression showed that NLR < 3 at baseline was associated with higher occurrence of irAEs. Multivariate Cox regression showed that development of irAEs and reduction in NLR from baseline to week 6 were associated with longer PFS. Higher NLR values at baseline and/or week 6 were independently associated with shorter OS. A reduction in NLR from baseline to week 6 was associated with longer OS. In this study of cancer patients treated with ICIs, NLR has a bidirectional relationship with adverse outcomes. Lower NLR was associated with increased occurrence of irAEs while higher NLR values were associated with worse clinical outcomes.
Source Title: CANCERS
URI: https://scholarbank.nus.edu.sg/handle/10635/208036
ISSN: 2072-6694
DOI: 10.3390/cancers13061308
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