Please use this identifier to cite or link to this item: https://doi.org/10.2147/PPA.S119719
Title: Utility of the Morisky Medication Adherence Scale in gout: a prospective study
Authors: Tan, CSL
Teng, GG 
Chong, KJ
Cheung, PP 
Lim, AYN
Wee, HL 
Santosa, A 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
gout
8-item Morisky Medication Adherence Scale
MMAS-8
serum urate
urate-lowering therapy
Singapore
URATE-LOWERING THERAPY
HEALTH-CARE COSTS
ADMINISTRATIVE CLAIMS
ALLOPURINOL THERAPY
SERUM URATE
PATIENT
ARTHRITIS
MANAGEMENT
PATTERNS
BARRIERS
Issue Date: 1-Jan-2016
Publisher: DOVE MEDICAL PRESS LTD
Citation: Tan, CSL, Teng, GG, Chong, KJ, Cheung, PP, Lim, AYN, Wee, HL, Santosa, A (2016-01-01). Utility of the Morisky Medication Adherence Scale in gout: a prospective study. Patient Preference and Adherence 10 : 2449-2457. ScholarBank@NUS Repository. https://doi.org/10.2147/PPA.S119719
Abstract: Background: The outcomes of any chronic illness often depend on patients’ adherence with their treatment. A tool is lacking to assess adherence in gout that is standardized, allows real-time feedback, and is easy to understand. Objective: We set out to evaluate the utility of the 8-item Morisky Medication Adherence Scale (MMAS-8) in monitoring medication adherence in a multiethnic Asian gout cohort on urate-lowering therapy (ULT). Methods: This cohort study recruited patients with gout where baseline and 6-monthly clinical data, self-report of adherence, and health status by Gout Impact Scale (GIS) and EuroQoL-5 dimension 3 levels were collected. Those who received at least 9 months of ULT were analyzed. Convergent and construct validities of MMAS-8 were evaluated against medication possession ratio (MPR) and known groups, clinical outcomes, and patient-reported outcomes. Internal consistency and test-retest reliability were assessed using Cronbach’s alpha and intraclass correlation coefficient (ICC), respectively. Results: Of 91 patients, 92.3% were male, 72.5% Chinese with mean age 53.5 years. MMAS-8 (mean 6.17) and MPR (mean 96.3%) were poorly correlated (r=0.069, P=0.521). MMAS-8 did not differ between those who did or did not achieve target serum urate (SU) <360 µmol/L (P=0.852); or among those whose SU improved, stagnated, or worsened during follow-up (P=0.777). Adherence was associated with age (β=0.256, P=0.015) and education level (P=0.011) but not comorbidities, polypharmacy, or flare frequency. Concerns for medication side effects and anxiety or depression were associated with lower MMAS-8 (P<0.005). Internal consistency was acceptable (α=0.725) and test-retest reliability was satisfactory (ICC =0.70, 95% confidence interval [CI] 0.36-0.88). Conclusion: MMAS-8 had limited construct validity in assessing medication adherence to ULT in our gout patients. Nevertheless, it identified patients bothered or worried about ULT side effects, and those with underlying anxiety or depression, for whom targeted education and coping support may be useful.
Source Title: Patient Preference and Adherence
URI: https://scholarbank.nus.edu.sg/handle/10635/207059
ISSN: 1177889X
DOI: 10.2147/PPA.S119719
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