Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.202108360
Title: Anti-Angiogenic Nanomicelles For the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease.
Authors: Zhao, Xinxin
Seah, Ivan
Xue, Kun
Wong, Wendy
Tan, Queenie Shu Woon
Ma, Xiao Xiao
Lin, Qianyu
Lim, Jason YC
LIU ZENGPING 
Parikh, Bhav Harshad
Mehta, Karishma N
Lai, Joel Weijia
Yang, Binxia
TRAN KIM CHI 
Barathi, Veluchamy Amutha
Cheong, Kang Hao
Hunziker, Walter
SU XINYI 
XIAN JUN LOH
Keywords: angiogenesis inhibitors
drug carriers
drug delivery systems
micelles
ophthalmic solutions
retinal diseases
Issue Date: 2-Nov-2021
Publisher: Wiley
Citation: Zhao, Xinxin, Seah, Ivan, Xue, Kun, Wong, Wendy, Tan, Queenie Shu Woon, Ma, Xiao Xiao, Lin, Qianyu, Lim, Jason YC, LIU ZENGPING, Parikh, Bhav Harshad, Mehta, Karishma N, Lai, Joel Weijia, Yang, Binxia, TRAN KIM CHI, Barathi, Veluchamy Amutha, Cheong, Kang Hao, Hunziker, Walter, SU XINYI, XIAN JUN LOH (2021-11-02). Anti-Angiogenic Nanomicelles For the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease.. Adv Mater : e2108360-. ScholarBank@NUS Repository. https://doi.org/10.1002/adma.202108360
Abstract: The traditional intravitreal injection delivery of anti-vascular endothelial growth factor (anti-VEGF) to the posterior segment of the eye for treatment of retinal diseases is invasive and associated with sight-threatening complications. To avoid such complications, there has been significant interest in developing polymers for topical drug delivery to the retina. This study reports a nanomicelle drug delivery system made of a co-polymer EPC (nEPCs), which is capable of delivering aflibercept to the posterior segment topically through corneal-scleral routes. EPC is comprised of polyethylene glycol (PEG), polypropylglycol (PPG) and polycaprolactone (PCL) segments. In this study, aflibercept-loaded nEPCs (nEPCs+A) is capable of penetrating the cornea in ex-vivo porcine eye models and deliver a clinically significant amount of aflibercept to the retina of laser-induced choroidal neovascularisation (CNV) murine models, causing CNV regression. nEPCs+A also demonstrates biocompatibility in-vitro and in-vivo. Interestingly, this study also suggests that nEPCs have intrinsic anti-angiogenic properties. The ability to deliver anti-VEGF drugs and the intrinsic anti-angiogenic properties of nEPCs may result in synergistic effects which can be harnessed for effective therapeutics. nEPCs may be a promising topical anti-VEGF delivery platform for the treatment of retinal diseases. This article is protected by copyright. All rights reserved.
Source Title: Adv Mater
URI: https://scholarbank.nus.edu.sg/handle/10635/206774
ISSN: 0935-9648
1521-4095
DOI: 10.1002/adma.202108360
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