Please use this identifier to cite or link to this item: https://doi.org/10.3389/fneur.2020.603571
Title: Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms
Authors: Chua, Regena Xin Yi 
Tay, Michelle Jia Yu 
Ooi, Delicia Shu Qin
Siah, Kewin Tien Ho 
Tham, Elizabeth Huiwen 
Shek, Lynette Pei-Chi 
Meaney, Michael J
Broekman, Birit FP 
Loo, Evelyn Xiu Ling 
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
allergic disease
neurodevelopmental disorder
mechanisms
attention deficit and hyperactivity disorder
autism spectral disorder
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
DEFICIT-HYPERACTIVITY DISORDER
AUTISM SPECTRUM DISORDERS
ATOPIC-DERMATITIS
CHILDHOOD ASTHMA
DNA METHYLATION
MATERNAL STRESS
ENVIRONMENTAL EXPOSURES
MERCURY EXPOSURE
SLEEP QUALITY
Issue Date: 15-Feb-2021
Publisher: FRONTIERS MEDIA SA
Citation: Chua, Regena Xin Yi, Tay, Michelle Jia Yu, Ooi, Delicia Shu Qin, Siah, Kewin Tien Ho, Tham, Elizabeth Huiwen, Shek, Lynette Pei-Chi, Meaney, Michael J, Broekman, Birit FP, Loo, Evelyn Xiu Ling (2021-02-15). Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms. FRONTIERS IN NEUROLOGY 11. ScholarBank@NUS Repository. https://doi.org/10.3389/fneur.2020.603571
Abstract: Both allergic diseases and neurodevelopmental disorders are non-communicable diseases (NCDs) that not only impact on the quality of life and but also result in substantial economic burden. Immune dysregulation and inflammation are typical hallmarks in both allergic and neurodevelopmental disorders, suggesting converging pathophysiology. Epidemiological studies provided convincing evidence for the link between allergy and neurodevelopmental diseases such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Possible factors influencing the development of these disorders include maternal depression and anxiety, gestational diabetes mellitus, maternal allergic status, diet, exposure to environmental pollutants, microbiome dysbiosis, and sleep disturbances that occur early in life. Moreover, apart from inflammation, epigenetics, gene expression, and mitochondrial dysfunction have emerged as possible underlying mechanisms in the pathogenesis of these conditions. The exploration and understanding of these shared factors and possible mechanisms may enable us to elucidate the link in the comorbidity.
Source Title: FRONTIERS IN NEUROLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/206718
ISSN: 16642295
DOI: 10.3389/fneur.2020.603571
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