Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0250102
Title: Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
Authors: Ho, Peh Joo
Yeoh, Yen Shing 
Miao, Hui 
Lim, Swee Ho 
Tan, Ern Yu
Tan, Benita Kiat Tee
Tan, Veronique Kiak Mien
Tan, Su Ming 
Yong, Wei Sean 
Wong, Fuh Yong 
Madhukumar, Preetha
Chan, Ching Wan 
Iau, Philip Tsau Choong
Lee, Soo Chin 
Putti, Thomas 
Buhari, Shaik Ahmad
Lee, Jin Yee 
Lim, Geok Hoon 
Woo, Evan
Yan, Zhiyan 
Chan, Patrick Mun Yew
Chen, Juliana Jia Chuan
Lu, Sarah Qinghui
Dent, Rebecca
Lee, Wai Peng 
Mok, Chi Wei 
Seah, Jaime Chin Mui
Sim, Xueling 
van Dam, Rob Martinus 
Chia, Kee Seng
Li, Jingmei 
Hartman, Mikael 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ASSOCIATION ANALYSIS
ETHNIC-DIFFERENCES
PERFORMANCE
Issue Date: 26-Apr-2021
Publisher: PUBLIC LIBRARY SCIENCE
Citation: Ho, Peh Joo, Yeoh, Yen Shing, Miao, Hui, Lim, Swee Ho, Tan, Ern Yu, Tan, Benita Kiat Tee, Tan, Veronique Kiak Mien, Tan, Su Ming, Yong, Wei Sean, Wong, Fuh Yong, Madhukumar, Preetha, Chan, Ching Wan, Iau, Philip Tsau Choong, Lee, Soo Chin, Putti, Thomas, Buhari, Shaik Ahmad, Lee, Jin Yee, Lim, Geok Hoon, Woo, Evan, Yan, Zhiyan, Chan, Patrick Mun Yew, Chen, Juliana Jia Chuan, Lu, Sarah Qinghui, Dent, Rebecca, Lee, Wai Peng, Mok, Chi Wei, Seah, Jaime Chin Mui, Sim, Xueling, van Dam, Rob Martinus, Chia, Kee Seng, Li, Jingmei, Hartman, Mikael (2021-04-26). Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers. PLOS ONE 16 (4). ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0250102
Abstract: This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers.
Source Title: PLOS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/206539
ISSN: 19326203
DOI: 10.1371/journal.pone.0250102
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