Please use this identifier to cite or link to this item: https://doi.org/10.1161/CIRCULATIONAHA.115.019392
Title: Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention
Authors: Lee, Chi-Hang 
Sethi, Rishi
Li, Ruogu
Ho, Hee-Hwa
Hein, Thet
Jim, Man-Hong
Loo, Germaine
KOO CHIEH YANG CHRISTOPHER 
Gao, Xiao-Fei
Chandra, Sharad
Yang, Xiao-Xiao
Furlan, Sofia F
Ge, Zhen
Mundhekar, Ajeya
Zhang, Wei-Wei
Uchoa, Carlos Henrique G
Kharwar, Rajiv Bharat
Chan, Po-Fun
Chen, Shao-Liang
Chan, M.Y. 
ARTHUR MARK RICHARDS 
Tan, Huay-Cheem 
Ong, Thun-How
Roldan, Glenn
Tai, B.C. 
Drager, Luciano F
Zhang, Jun-Jie
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Cardiovascular System & Cardiology
coronary artery disease
outcome assessment (health care)
percutaneous coronary intervention
risk factors
sleep apnea
obstructive
BERLIN QUESTIONNAIRE
DAYTIME SLEEPINESS
IMPACT
OUTCOMES
ATHEROSCLEROSIS
ASSOCIATION
RATIONALE
PREVALENCE
CARDIOLOGY
COMMITTEE
Issue Date: 24-May-2016
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Lee, Chi-Hang, Sethi, Rishi, Li, Ruogu, Ho, Hee-Hwa, Hein, Thet, Jim, Man-Hong, Loo, Germaine, KOO CHIEH YANG CHRISTOPHER, Gao, Xiao-Fei, Chandra, Sharad, Yang, Xiao-Xiao, Furlan, Sofia F, Ge, Zhen, Mundhekar, Ajeya, Zhang, Wei-Wei, Uchoa, Carlos Henrique G, Kharwar, Rajiv Bharat, Chan, Po-Fun, Chen, Shao-Liang, Chan, M.Y., ARTHUR MARK RICHARDS, Tan, Huay-Cheem, Ong, Thun-How, Roldan, Glenn, Tai, B.C., Drager, Luciano F, Zhang, Jun-Jie (2016-05-24). Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention. CIRCULATION 133 (21) : 2008-2017. ScholarBank@NUS Repository. https://doi.org/10.1161/CIRCULATIONAHA.115.019392
Abstract: Background - There is a paucity of data from large cohort studies examining the prognostic significance of obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) in patients undergoing percutaneous coronary intervention. Methods and Results - The Sleep and Stent Study was a prospective, multicenter registry of patients successfully treated with percutaneous coronary intervention in 5 countries. Between December 2011 and April 2014, 1748 eligible patients were prospectively enrolled. The 1311 patients who completed a sleep study within 7 days of percutaneous coronary intervention formed the cohort for this analysis. Drug-eluting stents were used in 80.1% and bioresorbable vascular scaffolds in 6.3% of the patients, and OSA, defined as an apnea-hypopnea index of ≥15 events per hour, was found in 45.3%. MACCEs, a composite of cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, and unplanned revascularization, occurred in 141 patients during the median follow-up of 1.9 years (interquartile range, 0.8 years). The crude incidence of an MACCEs was higher in the OSA than the non-OSA group (3-year estimate, 18.9% versus 14.0%; p=0.001). Multivariate Cox regression analysis indicated that OSA was a predictor of MACCEs, with an adjusted hazard ratio of 1.57 (95% confidence interval, 1.10-2.24; P=0.013), independently of age, sex, ethnicity, body mass index, diabetes mellitus, and hypertension. Conclusions - OSA is independently associated with subsequent MACCEs in patients undergoing percutaneous coronary intervention. Evaluation of therapeutic approaches to mitigate OSA-associated risk is warranted.
Source Title: CIRCULATION
URI: http://scholarbank.nus.edu.sg/handle/10635/123992
https://scholarbank.nus.edu.sg/handle/10635/206227
ISSN: 0009-7322
1524-4539
DOI: 10.1161/CIRCULATIONAHA.115.019392
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