Please use this identifier to cite or link to this item: https://doi.org/10.3892/etm.2021.9940
Title: Increased thalamo-cortical functional connectivity in patients with diabetic painful neuropathy: A resting-state functional MRI study
Authors: Liu, Xiaomei
Xu, Xianghong
Mao, Cunnan
Zhang, Peng
Zhang, Qing
Jiang, Lanlan
Yang, Yuyin
Ma, Jianhua
Ye, Lei
Lee, Kok-Onn 
Wu, Jindan
Yao, Zhijian
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
diabetes mellitus
resting-state functional MRI
functional connectivity
thalamo-cortical
painful neuropathy
imaging
Issue Date: 1-May-2021
Publisher: SPANDIDOS PUBL LTD
Citation: Liu, Xiaomei, Xu, Xianghong, Mao, Cunnan, Zhang, Peng, Zhang, Qing, Jiang, Lanlan, Yang, Yuyin, Ma, Jianhua, Ye, Lei, Lee, Kok-Onn, Wu, Jindan, Yao, Zhijian (2021-05-01). Increased thalamo-cortical functional connectivity in patients with diabetic painful neuropathy: A resting-state functional MRI study. EXPERIMENTAL AND THERAPEUTIC MEDICINE 21 (5). ScholarBank@NUS Repository. https://doi.org/10.3892/etm.2021.9940
Abstract: Functional changes in the brain of patients with painful diabetic neuropathy (PDN) have remained largely elusive. The aim of the present study was to explore changes in thalamo-cortical functional connectivity (FC) of patients with PDN using resting-state functional MRI. A total of 20 patients with type 2 diabetes mellitus (T2DM) with non-painful diabetic neuropathy (Group NDN), 19 patients with T2DM with PDN (Group-PDN) and 13 age-, sex- and education-matched healthy controls were recruited. The differences in thalamo-cortical FC among the three groups were compared. Patients in Group PDN had increased FC in the left thalamus, the right angular gyrus and the occipital gyrus as compared to those in Group NDN. Furthermore, patients in Group PDN had increased FC in the right thalamus and angular gyrus as compared to those in Group NDN. In conclusion, the present results suggested that the thalamo-cortical FC is increased in patients with T2DM and PDN. Furthermore, the increased FC in the thalamic-parietal-occipital connectivity may be a central pathophysiological mechanism for PDN. The study was retrospectively registered at ClinicalTrials.gov on 3 October 2018 (identifier no. NCT03700502).
Source Title: EXPERIMENTAL AND THERAPEUTIC MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/205930
ISSN: 17920981
17921015
DOI: 10.3892/etm.2021.9940
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