Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jhsa.2018.10.023
Title: Structural Adaptations of the Primate Flexor Carpi Ulnaris After Tendon Transfer
Authors: Das De, Soumen
Pereira, Barry
Sebastin, Sandeep J 
Kumar, Prem VP 
Lim, Aymeric YT
Keywords: Science & Technology
Life Sciences & Biomedicine
Orthopedics
Surgery
Muscle plasticity
primate
structural adaptations
tendon transfer
MUSCLE-FIBER TYPES
SKELETAL-MUSCLE
FOREARM
MONKEY
BIOMECHANICS
TENSION
POINTS
LENGTH
Issue Date: 1-Sep-2019
Publisher: W B SAUNDERS CO-ELSEVIER INC
Citation: Das De, Soumen, Pereira, Barry, Sebastin, Sandeep J, Kumar, Prem VP, Lim, Aymeric YT (2019-09-01). Structural Adaptations of the Primate Flexor Carpi Ulnaris After Tendon Transfer. JOURNAL OF HAND SURGERY-AMERICAN VOLUME 44 (9). ScholarBank@NUS Repository. https://doi.org/10.1016/j.jhsa.2018.10.023
Abstract: Purpose: Muscle remodeling occurs after tendon transfer. However, it is not known whether these adaptations are permanent and clinically significant. This study examined the early and late structural adaptations following a standard tendon transfer in a primate model. Methods: A flexor carpi ulnaris (FCU) to extensor digitorum communis (EDC) transfer was performed in 8 adult monkeys. A sham operation was performed in the contralateral forearm. Four animals were sacrificed at 5 months (early cohort) and 4 at 16 months (late cohort). The transferred FCU, contralateral FCU, and EDC muscles were removed for analysis. Fiber length (FL), physiological cross-sectional area (PCSA), and gross morphology of the transferred FCU were compared with the contralateral EDC and FCU. Results: In the early cohort, the FL of the transferred FCU was longer than the control FCU and similar to the contralateral EDC. The PCSA of the transferred FCU was lower than that of the control FCU but greater than the control EDC. In the late cohort, the difference in FL and PCSA between the transferred FCU and the control FCU persisted. The PCSA of the transferred FCU was similar to that of the control EDC. The bipennate transferred FCU had also undergone gross morphological changes to resemble the multipennate EDC. Conclusions: This study demonstrates, in a primate model, that the FCU undergoes structural adaptations to resemble the EDC following an FCU-to-EDC transfer. However, these adaptations are incomplete and not sustained over time. Clinical relevance: This study demonstrates that there is muscle plasticity in tendon transfers in a primate model. However, it is important to match potential donor muscles to the recipient during tendon transfer.
Source Title: JOURNAL OF HAND SURGERY-AMERICAN VOLUME
URI: https://scholarbank.nus.edu.sg/handle/10635/205927
ISSN: 03635023
15316564
DOI: 10.1016/j.jhsa.2018.10.023
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Structural Adaptations of the Primate Flexor Carpi Ulnaris After Tendon Transfer(2).pdf469.46 kBAdobe PDF

CLOSED

None

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.