Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-019-46486-0
Title: Independent Predictors of Cardiac Mortality and Hospitalization for Heart Failure in a Multi-Ethnic Asian ST-segment Elevation Myocardial Infarction Population Treated by Primary Percutaneous Coronary Intervention
Authors: Bulluck, Heerajnarain
Zheng, Huili 
Chan, Mark Y 
Foin, Nicolas
Foo, David C
Lee, Chee W 
Lim, Soo T 
Sahlen, Anders 
Tan, Huay C 
Tan, Jack W 
Tong, Khim L 
Wong, Aaron S
Wong, Philip E
Yeo, Khung K 
Foo, Ling L
Chua, Terrance S
Koh, Tian H 
Hausenloy, Derek J 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RISK SCORES
MANAGEMENT
TIMI
Issue Date: 11-Jul-2019
Publisher: NATURE PUBLISHING GROUP
Citation: Bulluck, Heerajnarain, Zheng, Huili, Chan, Mark Y, Foin, Nicolas, Foo, David C, Lee, Chee W, Lim, Soo T, Sahlen, Anders, Tan, Huay C, Tan, Jack W, Tong, Khim L, Wong, Aaron S, Wong, Philip E, Yeo, Khung K, Foo, Ling L, Chua, Terrance S, Koh, Tian H, Hausenloy, Derek J (2019-07-11). Independent Predictors of Cardiac Mortality and Hospitalization for Heart Failure in a Multi-Ethnic Asian ST-segment Elevation Myocardial Infarction Population Treated by Primary Percutaneous Coronary Intervention. SCIENTIFIC REPORTS 9 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-46486-0
Abstract: We aimed to identify independent predictors of cardiac mortality and hospitalization for heart failure (HHF) from a real-world, multi-ethnic Asian registry [the Singapore Myocardial Infarction Registry] of ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention. 11,546 eligible STEMI patients between 2008 and 2015 were identified. In-hospital, 30-day and 1-year cardiac mortality and 1-year HHF rates were 6.4%, 6.8%, 8.3% and 5.2%, respectively. From the derivation cohort (70% of patients), age, Killip class and cardiac arrest, creatinine, hemoglobin and troponin on admission and left ventricular ejection fraction (LVEF) during hospitalization were predictors of in-hospital, 30-day and 1-year cardiac mortality. Previous ischemic heart disease (IHD) was a predictor of in-hospital and 30-day cardiac mortality only, whereas diabetes was a predictor of 1-year cardiac mortality only. Age, previous IHD and diabetes, Killip class, creatinine, hemoglobin and troponin on admission, symptom-to-balloon-time and LVEF were predictors of 1-year HHF. The c-statistics were 0.921, 0.901, 0.881, 0.869, respectively. Applying these models to the validation cohort (30% of patients) showed good fit and discrimination (c-statistic 0.922, 0.913, 0.903 and 0.855 respectively; misclassification rate 14.0%, 14.7%, 16.2% and 24.0% respectively). These predictors could be incorporated into specific risk scores to stratify reperfused STEMI patients by their risk level for targeted intervention.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/205892
ISSN: 20452322
DOI: 10.1038/s41598-019-46486-0
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