Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-021-86003-w
Title: Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention
Authors: Sia, Ching-Hui 
Ko, Junsuk
Zheng, Huili 
Ho, Andrew Fu-Wah
Foo, David
Foo, Ling-Li
Lim, Patrick Zhan-Yun
Liew, Boon Wah 
Chai, Ping 
Yeo, Tiong-Cheng 
Tan, Huay-Cheem 
Chua, Terrance
Chan, Mark Yan-Yee 
Tan, Jack Wei Chieh 
Bulluck, Heerajnarain
Hausenloy, Derek J 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Issue Date: 19-Mar-2021
Publisher: NATURE RESEARCH
Citation: Sia, Ching-Hui, Ko, Junsuk, Zheng, Huili, Ho, Andrew Fu-Wah, Foo, David, Foo, Ling-Li, Lim, Patrick Zhan-Yun, Liew, Boon Wah, Chai, Ping, Yeo, Tiong-Cheng, Tan, Huay-Cheem, Chua, Terrance, Chan, Mark Yan-Yee, Tan, Jack Wei Chieh, Bulluck, Heerajnarain, Hausenloy, Derek J (2021-03-19). Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention. SCIENTIFIC REPORTS 11 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-86003-w
Abstract: Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed the “smoker’s paradox.” Given the known detrimental effects of smoking on the cardiovascular system, it has been proposed that the beneficial effect of smoking on outcomes is due to age differences between smokers and non-smokers and is therefore a smoker’s pseudoparadox. The aim of this study was to evaluate the association between smoking status and clinical outcomes in ST-segment elevation (STEMI) and non-STEMI (NSTEMI) patients treated by percutaneous coronary intervention (PCI), using a national multi-ethnic Asian registry. In unadjusted analyses, current smokers had better clinical outcomes following STEMI and NSTEMI. However, after adjusting for age, the protective effect of smoking was lost, confirming a smoker’s pseudoparadox. Interestingly, although current smokers had increased risk for recurrent MI within 1 year after PCI in both STEMI and NSTEMI patients, there was no increase in mortality. In summary, we confirm the existence of a smoker’s pseudoparadox in a multi-ethnic Asian cohort of STEMI and NSTEMI patients and report increased risk of recurrent MI, but not mortality, in smokers.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/205774
ISSN: 20452322
DOI: 10.1038/s41598-021-86003-w
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