Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.immuni.2019.08.013
| Title: | The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality | Authors: | Li, Chaofan Zhu, Bibo Son, Young Min Wang, Zheng Jiang, Li Xiang, Min Ye, Zhenqing Beckermann, Kathryn E Wu, Yue Jenkins, James W Siska, Peter J Vincent, Benjamin G Prakash, YS Peikert, Tobias Edelson, Brian T RESHMA TANEJA Kaplan, Mark H Rathmell, Jeffrey C Dong, Haidong Hitosugi, Taro Sun, Jie |
Keywords: | Science & Technology Life Sciences & Biomedicine Immunology TISSUE-RESIDENT TUMOR MICROENVIRONMENT DENDRITIC CELLS MEMORY INFECTION PD-L1 ACTIVATION IMMUNITY SUPPRESSION DYSFUNCTION |
Issue Date: | 17-Sep-2019 | Publisher: | CELL PRESS | Citation: | Li, Chaofan, Zhu, Bibo, Son, Young Min, Wang, Zheng, Jiang, Li, Xiang, Min, Ye, Zhenqing, Beckermann, Kathryn E, Wu, Yue, Jenkins, James W, Siska, Peter J, Vincent, Benjamin G, Prakash, YS, Peikert, Tobias, Edelson, Brian T, RESHMA TANEJA, Kaplan, Mark H, Rathmell, Jeffrey C, Dong, Haidong, Hitosugi, Taro, Sun, Jie (2019-09-17). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality. IMMUNITY 51 (3) : 491-507. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2019.08.013 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International | Abstract: | The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy. | Source Title: | IMMUNITY | URI: | https://scholarbank.nus.edu.sg/handle/10635/200311 | ISSN: | 1074-7613 1097-4180 |
DOI: | 10.1016/j.immuni.2019.08.013 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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