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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.immuni.2019.08.013
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dc.titleThe Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality
dc.contributor.authorLi, Chaofan
dc.contributor.authorZhu, Bibo
dc.contributor.authorSon, Young Min
dc.contributor.authorWang, Zheng
dc.contributor.authorJiang, Li
dc.contributor.authorXiang, Min
dc.contributor.authorYe, Zhenqing
dc.contributor.authorBeckermann, Kathryn E
dc.contributor.authorWu, Yue
dc.contributor.authorJenkins, James W
dc.contributor.authorSiska, Peter J
dc.contributor.authorVincent, Benjamin G
dc.contributor.authorPrakash, YS
dc.contributor.authorPeikert, Tobias
dc.contributor.authorEdelson, Brian T
dc.contributor.authorRESHMA TANEJA
dc.contributor.authorKaplan, Mark H
dc.contributor.authorRathmell, Jeffrey C
dc.contributor.authorDong, Haidong
dc.contributor.authorHitosugi, Taro
dc.contributor.authorSun, Jie
dc.date.accessioned2021-09-08T03:32:22Z
dc.date.available2021-09-08T03:32:22Z
dc.date.issued2019-09-17
dc.identifier.citationLi, Chaofan, Zhu, Bibo, Son, Young Min, Wang, Zheng, Jiang, Li, Xiang, Min, Ye, Zhenqing, Beckermann, Kathryn E, Wu, Yue, Jenkins, James W, Siska, Peter J, Vincent, Benjamin G, Prakash, YS, Peikert, Tobias, Edelson, Brian T, RESHMA TANEJA, Kaplan, Mark H, Rathmell, Jeffrey C, Dong, Haidong, Hitosugi, Taro, Sun, Jie (2019-09-17). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality. IMMUNITY 51 (3) : 491-507. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2019.08.013
dc.identifier.issn1074-7613
dc.identifier.issn1097-4180
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/200311
dc.description.abstractThe molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.
dc.language.isoen
dc.publisherCELL PRESS
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectImmunology
dc.subjectTISSUE-RESIDENT
dc.subjectTUMOR MICROENVIRONMENT
dc.subjectDENDRITIC CELLS
dc.subjectMEMORY
dc.subjectINFECTION
dc.subjectPD-L1
dc.subjectACTIVATION
dc.subjectIMMUNITY
dc.subjectSUPPRESSION
dc.subjectDYSFUNCTION
dc.typeArticle
dc.date.updated2021-09-08T02:37:01Z
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.immuni.2019.08.013
dc.description.sourcetitleIMMUNITY
dc.description.volume51
dc.description.issue3
dc.description.page491-507
dc.published.statePublished
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