Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.breast.2020.06.012
Title: Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: A randomised controlled trial to evaluate the effect of short message service (SMS) reminder
Authors: Tan, E.H.
Wong, A.L.A.
Tan, C.C.
Wong, P.
Tan, S.H.
Ang, L.E.Y.
Lim, S.E.
Chong, W.Q.
Ho, J.
Lee, S.C.
Tai, B.C. 
Keywords: Adherence
Aromatase inhibitor
Breast cancer
Randomised controlled trial
SMS reminder
Issue Date: 2020
Publisher: Churchill Livingstone
Citation: Tan, E.H., Wong, A.L.A., Tan, C.C., Wong, P., Tan, S.H., Ang, L.E.Y., Lim, S.E., Chong, W.Q., Ho, J., Lee, S.C., Tai, B.C. (2020). Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: A randomised controlled trial to evaluate the effect of short message service (SMS) reminder. Breast 53 : 77-84. ScholarBank@NUS Repository. https://doi.org/10.1016/j.breast.2020.06.012
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Background: Medication adherence is crucial for improving clinical outcomes in the treatment of patients. We evaluate the effect of short message service (SMS) reminder on medication adherence and serum hormones in patients with breast cancer on aromatase inhibitors. Methods: An open-label, multi-centre, prospective randomised controlled trial of SMS versus Standard Care was conducted. Medication adherence was assessed via self-report using the Simplified Medication Adherence Questionnaire at baseline, 6 month, and 1 year. Androstenedione, estradiol, and estrone were measured at baseline and 1 year. The ?2 test and mixed effects logistic regression was performed to compare medication adherence between groups. Difference in androstenedione and estrone levels were assessed using analysis of covariance, whereas ?2 test and logistic regression was used for estradiol. Analysis was based on intention-to-treat. Results: A total of 244 patients were randomised to receive weekly SMS reminder (n = 123) or Standard Care (n = 121) between May 2015 and December 2018. The odds of adherence was higher at 6-month in SMS (OR = 1.78, 95% CI 1.04–3.05, p = 0.034), and not significantly different at 1-year (OR = 1.15, 95% CI: 0.67–1.96 p = 0.617). Mixed effects logistic regression analysis showed higher odds of adherence in SMS over the 1-year period (OR = 2.35, 95% CI: 1.01–5.49, p = 0.048). There was no difference in serum hormone levels between groups. Conclusion: SMS reminder improved medication adherence in the short-term but had no effect on serum hormones levels in the longer term. Future studies could investigate the use of tailored SMS intervention according to patient preference to improve its sustainability. © 2020 The Authors
Source Title: Breast
URI: https://scholarbank.nus.edu.sg/handle/10635/199704
ISSN: 0960-9776
DOI: 10.1016/j.breast.2020.06.012
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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