Please use this identifier to cite or link to this item: https://doi.org/10.3390/ani10101906
Title: Large animal models of heart failure: Reduced vs. preserved ejection fraction
Authors: Charles, C.J. 
Rademaker, M.T.
Scott, N.J.A.
Richards, A.M.
Keywords: Animal model
Ejection fraction
Heart failure
HFpEF
HFrEF
Ovine
Porcine
Issue Date: 2020
Publisher: MDPI AG
Citation: Charles, C.J., Rademaker, M.T., Scott, N.J.A., Richards, A.M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals 10 (10) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.3390/ani10101906
Rights: Attribution 4.0 International
Abstract: Heart failure (HF) is the final common end point of multiple metabolic and cardiovascular diseases and imposes a significant health care burden worldwide. Despite significant improvements in clinical management and outcomes, morbidity and mortality remain high and there remains an indisputable need for improved treatment options. The pathophysiology of HF is complex and covers a spectrum of clinical presentations from HF with reduced ejection fraction (HFrEF) (?40% EF) through to HF with preserved EF (HFpEF), with HFpEF patients demonstrating a reduced ability of the heart to relax despite an EF maintained above 50%. Prior to the last decade, the majority of clinical trials and animal models addressed HFrEF. Despite growing efforts recently to understand underlying mechanisms of HFpEF and find effective therapies for its treatment, clinical trials in patients with HFpEF have failed to demonstrate improvements in mortality. A significant obstacle to therapeutic innovation in HFpEF is the absence of preclinical models including large animal models which, unlike rodents, permit detailed instrumentation and extensive imaging and sampling protocols. Although several large animal models of HFpEF have been reported, none fulfil all the features present in human disease and few demonstrate progression to frank decompensated HF. This review summarizes well-established models of HFrEF in pigs, dogs and sheep and discusses attempts to date to model HFpEF in these species. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Animals
URI: https://scholarbank.nus.edu.sg/handle/10635/199696
ISSN: 2076-2615
DOI: 10.3390/ani10101906
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_ani10101906.pdf1.51 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

2
checked on Jan 22, 2022

Page view(s)

39
checked on Jan 27, 2022

Download(s)

2
checked on Jan 27, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons