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Title: Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function
Authors: Ravikumar, M.
Smith, R.A.A.
Nurcombe, V.
Cool, S.M. 
Keywords: adult stem cells
embryonic stem cells
extracellular matrix
heparan sulfate
stem cells
Issue Date: 2020
Publisher: Frontiers Media S.A.
Citation: Ravikumar, M., Smith, R.A.A., Nurcombe, V., Cool, S.M. (2020). Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function. Frontiers in Cell and Developmental Biology 8 : 581213. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and the surrounding microenvironment. Evidence has shown that heterogeneity in HSPG composition is crucial to its functions as an essential scaffolding component in the extracellular matrix as well as a vital cell surface signaling co-receptor. Here, we provide an overview of the significance of HSPGs as essential regulators of stem cell function. We discuss the various roles of HSPGs in distinct stem cell types during key physiological events, from development through to tissue homeostasis and regeneration. The contribution of aberrant HSPG production to altered stem cell properties and dysregulated cellular homeostasis characteristic of cancer is also reviewed. Finally, we consider approaches to better understand and exploit the multifaceted functions of HSPGs in influencing stem cell characteristics for cell therapy and associated culture expansion strategies. © Copyright © 2020 Ravikumar, Smith, Nurcombe and Cool.
Source Title: Frontiers in Cell and Developmental Biology
ISSN: 2296634X
DOI: 10.3389/fcell.2020.581213
Rights: Attribution 4.0 International
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