Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41541-021-00370-z
Title: Codominant IgG and IgA expression with minimal vaccine mRNA in milk of BNT162b2 vaccinees
Authors: Low, Jia Ming 
Gu, Yue
Ng, Melissa Shu Feng
Amin, Zubair 
Lee, Le Ye
Ng, Yvonne Peng Mei 
Shunmuganathan, Bhuvaneshwari DO 
Niu, Yuxi 
Gupta, Rashi 
Tambyah, Paul Anantharajah 
MacAry, Paul A 
Wang, Liang Wei
Zhong, Youjia 
Issue Date: Dec-2021
Publisher: Springer Science and Business Media LLC
Citation: Low, Jia Ming, Gu, Yue, Ng, Melissa Shu Feng, Amin, Zubair, Lee, Le Ye, Ng, Yvonne Peng Mei, Shunmuganathan, Bhuvaneshwari DO, Niu, Yuxi, Gupta, Rashi, Tambyah, Paul Anantharajah, MacAry, Paul A, Wang, Liang Wei, Zhong, Youjia (2021-12). Codominant IgG and IgA expression with minimal vaccine mRNA in milk of BNT162b2 vaccinees. npj Vaccines 6 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41541-021-00370-z
Abstract: Lactating women can produce protective antibodies in their milk after vaccination, which has informed antenatal vaccination programs for diseases such as influenza and pertussis. However, whether SARS-CoV-2-specific antibodies are produced in human milk as a result of COVID-19 vaccination is still unclear. In this study, we show that lactating mothers who received the BNT162b2 vaccine secreted SARS-CoV-2-specific IgA and IgG antibodies into milk, with the most significant increase at 3–7 days post-dose 2. Virus-specific IgG titers were stable out to 4–6 weeks after dose 2. In contrast, SARS-CoV-2-specific IgA levels showed substantial decay. Vaccine mRNA was detected in few milk samples (maximum of 2 ng/ml), indicative of minimal transfer. Additionally, infants who consumed post-vaccination human milk had no reported adverse effects up to 28 days post-ingestion. Our results define the safety and efficacy profiles of the vaccine in this demographic and provide initial evidence for protective immunity conferred by milk-borne SARS-CoV-2-specific antibodies. Taken together, our study supports recommendations for uninterrupted breastfeeding subsequent to mRNA vaccination against COVID-19.
Source Title: npj Vaccines
URI: https://scholarbank.nus.edu.sg/handle/10635/198869
ISSN: 20590105
DOI: 10.1038/s41541-021-00370-z
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